1-BENZYL-4-(ETHOXYCARBONYLMETHYL)PIPERAZINE synthesis
- Product Name:1-BENZYL-4-(ETHOXYCARBONYLMETHYL)PIPERAZINE
- CAS Number:23173-76-4
- Molecular formula:C15H22N2O2
- Molecular Weight:262.35
Yield:23173-76-4 100%
Reaction Conditions:
in benzene at 20; for 2 h;
Steps:
4.1 ethyl 4-benzylpiperazineacetate
4-Benzylpiperazine(3.3 ml, 18.9 mmol) was added to a solution of ethyl bromoacetate(1 ml, 9.0 mmol) in benzene(9 ml), which was then stirred for 2 hours at a room temperature, diluted with ethyl ether, and washed with saturated NaCl solution. The separated organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2.38 g of the titled compound. (Yield 100%). NMR(CDCl3): 1.3(t, 3H), 2.6(t, 8H), 3.2(s, 2H), 3.6(s, 2H), 4.2(q, 2H), 7.3(m, 5H).
References:
US6352993,2002,B1 Location in patent:Page column 13-14
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