1-ACETYL-4-CYANO-7-AZAINDOLE synthesis

2synthesis methods

Product Name:1-ACETYL-4-CYANO-7-AZAINDOLE
CAS Number:618446-36-9
Molecular formula:C10H7N3O
Molecular Weight:185.18

Ethanone, 1-(4-iodo-1H-pyrrolo[2,3-b]pyridin-1-yl)-

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Yield:-

Reaction Conditions:

with 1,1'-bis-(diphenylphosphino)ferrocene;copper(l) cyanide;tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ in 1,4-dioxane; for 2 h;Heating / reflux;

Steps:

CCXXIV Preparation CCXXIV 1-acetyl-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

A mixture of 1-(4-iodo-pyrrolo[2,3-b]pyridin-1-yl)-ethanone (4.30 g), CuCN (6.841 g), Pd2 dba3 (0.729 g), and dppf (1.636 g) in 85 mL of dioxane was heated to reflux for 2 h. Solid was removed by filtration through a pad of Celite. The filtrate was concentrated to give a yellow solid as crude compound, which was purified by chromatography through silica gel (250 g, 5-30% EtOAc/hexanes, stepwise gradient) to afford 1-acetyl-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile as a white fluffy solid.

References:

US2003/225106,2003,A1 Location in patent:Page 95

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inquiry

References

1-ACETYL-4-CYANO-7-AZAINDOLE Related Search:

4-CYANO-7-AZAINDOLE 1H-Pyrrolo[2,3-b]pyridine, 1-acetyl- (9CI)