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ChemicalBook CAS DataBase List 1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE
87394-54-5

1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE synthesis

6synthesis methods
-

Yield:87394-54-5 90%

Reaction Conditions:

in water;acetonitrile;

Steps:

4 1-(6-Chloro-2-pyridinyl)piperazine

EXAMPLE 4 1-(6-Chloro-2-pyridinyl)piperazine A mixture of 2.6-dichloropyridine (4.0 g), anhydrous piperazine (6.97 g), and micropulverized anhydrous K2 CO3 (7.45 g) in acetonitrile (50 ml) was heated at reflux with stirring while under N2 atmosphere for 20 h. The excess acetonitrile was removed under reduced pressure and water (15 mL) added to the concentrate. The aqueous phase was extracted with CH2 Cl2 (3*50 mL). The combined CH2 Cl2 extracts were washed with sat. NaCl solution, dried with anhydrous MgSO4, are concentrated under reduced pressure. Silica gel chromatc,graphy (CH2 Cl2 /MeOH/NH4 OH; 94:6:0.6) of the residue yielded 1-(6-chloro-2-pyridinyl)piperazine (4.80 g; 90%).

References:

US4954502,1990,A

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