ChemicalBook CAS DataBase List 1-(4-(trifluoromethylsulfonyl)phenyl)ethanone

1-(4-(trifluoromethylsulfonyl)phenyl)ethanone synthesis

5synthesis methods

Product Name:1-(4-(trifluoromethylsulfonyl)phenyl)ethanone
CAS Number:432-86-0
Molecular formula:C9H7F3O3S
Molecular Weight:252.21

887144-94-7 Synthesis

1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one

887144-94-7
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13329-40-3 Synthesis

13329-40-3
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$6.00/5g

1-(4-(trifluoromethylsulfonyl)phenyl)ethanone

432-86-0
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Yield:432-86-0 92%

Reaction Conditions:

Stage #1: 4-Iodoacetophenonewith (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;tert-butylammonium hexafluorophosphate(V);caesium carbonate;Aminoiminomethanesulfinic acid in N,N-dimethyl-formamide at 90; for 2.5 h;Inert atmosphere;
Stage #2: Togni's reagent II in N,N-dimethyl-formamide at 25; for 1 h;Inert atmosphere;

Steps:

36 Preparation of compound 5d:

Add 4'-iodoacetophenone (49.2mg, 0.2mmol), thiourea dioxide (32.4mg, 0.3mmol), PdCl2dppf (11.0mg, 0.015mmol), nBu4NPF6 (38.7mg) to the reaction tube under a nitrogen atmosphere , 0.1mmol), Cs2CO3 (130.4mg, 0.4mmol) and redistilled solvent DMF (2mL) were reacted at 90°C for 2.5 hours. After cooling to room temperature, Togni's Reagent II reagent (69.6 mg, 0.22 mmol) was added to the system, and stirred at room temperature (25° C.) for 1 hour. After the reaction, water was added to the system to quench the reaction, extracted with ethyl acetate four times, the organic phases were combined and then washed with saturated brine once, dried over anhydrous Na2SO4, concentrated under reduced pressure, and purified by column chromatography (PE/EA =10:1, Rf=0.2) 46.4mg of yellow solid 5d was obtained, and the yield was 92%.

References:

CN113527158,2021,A Location in patent:Paragraph 0175-0178

2926-29-6 Synthesis