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1-(4-METHYLPHENYL)-5-(TRIFLUOROMETHYL)-& synthesis

1synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: acetic anhydride / 4 h / 130 °C
1.2: 5 h / 100 °C
2.1: lithium hydroxide / tetrahydrofuran; water / 1 h / 80 °C

References:

Wu, Zhibing;Park, Hyung-Yeon;Xie, Dewen;Yang, Jingxin;Hou, Shuaitao;Shahzad, Nasir;Kim, Chan Kyung;Yang, Song [Journal of Agricultural and Food Chemistry,2021,vol. 69,# 4,p. 1214 - 1223]

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