1-(4-CHLOROPHENYL)-2-(4-METHYLPHENYL)ETHAN-1-ONE synthesis
- Product Name:1-(4-CHLOROPHENYL)-2-(4-METHYLPHENYL)ETHAN-1-ONE
- CAS Number:15221-84-8
- Molecular formula:C15H13ClO
- Molecular Weight:244.72
Yield:15221-84-8 57%
Reaction Conditions:
Stage #1: toluenewith thianthrene-5-oxide;trifluoromethylsulfonic anhydride in acetonitrile at -20 - 20; for 0.666667 h;Inert atmosphere;Schlenk technique;
Stage #2: para-chloroacetophenonewith palladium diacetate;cesium fluoride;XPhos in N,N-dimethyl-formamide;acetonitrile at 80; for 11 h;Inert atmosphere;Schlenk technique;
References:
Huang, Yu-Hao;Nie, Xiao-Xue;Wang, Peng [Organic Letters,2020,vol. 22,# 19,p. 7716 - 7720] Location in patent:supporting information
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