ChemicalBook CAS DataBase List 1-(3-CHLOROPYRIDIN-2-YL)PIPERAZINE

1-(3-CHLOROPYRIDIN-2-YL)PIPERAZINE synthesis

4synthesis methods

Product Name:1-(3-CHLOROPYRIDIN-2-YL)PIPERAZINE
CAS Number:87394-55-6
Molecular formula:C9H12ClN3
Molecular Weight:197.66

tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate

683240-45-1
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$289.00/1g

87394-55-6
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$45.00/100mg

Yield:87394-55-6 100%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 2.5 h;

Steps:

2.2A.2B

Step 2B; To a clear solution of tert-butyl 4-(3-chloropyridin-2-yl)piperazine-l- carboxylate in anhydrous dichloromethane (25 mL) was added TFA (25 mL) dropwise. The yellow solution was stirred at room temperature for 2.5 hour. Reaction was complete as determined by TLC. TFA was azeotropped with dichloroethane to give l-(3-chloropyridin-2- yl)piperazine in quantitative yield (1.265 g).IH NMR (400 MHz, DMSO-D6) δ ppm 3.19 - 3.32 (m, 4 H) 3.39 - 3.51 (m, 4 H) 7.10 (dd, J=7.83, 4.55 Hz, 2 H) 7.87 (dd, J=7.83, 1.52 Hz, 2 H) 8.27 (dd, J=4.80, 1.52 Hz, 2 H) 8.87 (s, I H).

References:

WO2007/92435,2007,A2 Location in patent:Page/Page column 92

110-85-0 Synthesis