1-(2-Chloroethyl)pyrrolidine Hydrochloride synthesis
- Product Name:1-(2-Chloroethyl)pyrrolidine Hydrochloride
- CAS Number:7250-67-1
- Molecular formula:C6H13Cl2N
- Molecular Weight:170.08
2955-88-6
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$8.00/5g
7250-67-1
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$10.00/5g
Yield:7250-67-1 46%
Reaction Conditions:
with thionyl chloride for 1 h;Heating / reflux;
Steps:
KK
2- pyrrolidin-1-ylethanol (6.24 g, 0.05 mol) was stirred while cautiously adding thionyl chloride (40 ml_, 0.54 mol). The stirred mixture was refluxed for 1 hour under nitrogen atmosphere, then concentrated in vacuo. The residue was triturated with diethyl ether to give a solid, and the liquid decanted; this process was repeated several times, until the decantate was almost colorless. The flask containing solid was evaporated to give a free- flowing, cocoa-colored solid (4.21 g, 46%). 1H-NMR (CD2 Cl2): δ 13.1 (br s, 1 H), 3.97 (t, 3 H), 3.7 (m, 2 H), 3.33 (dd, 2 H), 2.81 (m, 2 H), 2.14 - 1.95 (m, 3 H).
References:
BAYER PHARMACEUTICALS CORPORATION WO2007/56170, 2007, A2 Location in patent:Page/Page column 108
