1-(2-Bromophenylsulfonyl)pyrrolidine synthesis
- Product Name:1-(2-Bromophenylsulfonyl)pyrrolidine
- CAS Number:929000-58-8
- Molecular formula:C10H12BrNO2S
- Molecular Weight:290.18
123-75-1
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$10.00/5g
2905-25-1
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$12.00/1g
929000-58-8
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$65.00/250mg
Yield:929000-58-8 95%
Reaction Conditions:
in 1,4-dioxane at 10;
Steps:
Intermediate 64. 1 -((2-Bromophenyl)su Ifonyl)pyrrol idi ne
To a solution of 2-bromobenzenesulfonyl chloride (1.0 g, 3.91 mmol) in dry dioxane (10 mL) at approximately 10 00 was added dropwise pyrrolidine (0.65 mL, 7.81 mmol). The mixture was warmed to room temperature and stirred for 0.5 hrs. EtOAc (100 mL) was added and the organic layer was washed with H20 (3 x 30 mL) and brine (30 mL) passed through a phase separation cartridge and the solvent removed under reduced pressure to give the title compound as a yellow oil (1.24 g >95%).1H NMR (ppm)(400 MHz, CDCI3): 1.89-1.94 (4H, m), 3.39-3.44 (4H, m), 7.35-7.46 (2H, m),7.74 (IH, dd, J=1.3, 7.8 Hz), 8.12 (IH, dd, J1.8, 7.8 Hz)
References:
WO2016/170009,2016,A1 Location in patent:Page/Page column 71
108-86-1
508 suppliers
$10.00/5g
929000-58-8
37 suppliers
$65.00/250mg