1-(2,4,6-Trichlorophenyl)propan-2-one synthesis

7synthesis methods

Product Name:1-(2,4,6-Trichlorophenyl)propan-2-one
CAS Number:1228284-86-3
Molecular formula:C9H7Cl3O
Molecular Weight:237.51

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Yield:1228284-86-3 90%

Reaction Conditions:

with N-chloro-succinimide in tetrachloromethane at 50 - 60; for 5 h;

Steps:

2.2 (2) Synthesis of 2 , 4 , 6 -trichloropropiophenone

In a 250 mL four-neck reaction flask equipped with a stirrer, a thermometer, and a condenser, 16.8 g (0.1 mol) of 1-(4-chlorophenyl)acetone-2, and 100 ml of carbon tetrachloride were added.The mixture was heated to 50-60 ° C, and 29.4 g (0.22 mol) of N-chlorosuccinimide was added in portions. After the addition was completed, the reaction was continued for 5 hours.After cooling, 100 g of water was added, and the organic layer was separated, and the aqueous layer was extracted with carbonic acid, and the organic phase was combined, washed with water, dried over anhydrous magnesium sulfate and concentrated, and the obtained solid was recrystallized from 1:1 methanol.A brownish yellow solid was obtained in 21.3 g, yield 90%.

References:

CN108610290,2018,A Location in patent:Paragraph 0021; 0028; 0029