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ChemicalBook >> CAS DataBase List >> XL765

XL765

XL765 price.
  • $31 - $1725
  • Product name: XL765
  • CAS: 1349796-36-6
  • MF: C31H29N5O6S
  • MW: 599.66
  • EINECS:
  • MDL Number:MFCD18252649
  • Synonyms:SAR245409 (XL765);PI3K-IN-1;N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide;Benzamide, N-[4-[[[3-[(3,5-dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methyl-;Voxtalisib (SAR245409, XL765);N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide SAR245409 (XL765);XL765 N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide;N-(4-(N-(3-((3,5-Dimethoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylben
30 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 10mM(in 1mL DMSO)
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1137-M001
  • Product descriptionXL765 ≥95%
  • Packaging1mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1137-M005
  • Product descriptionXL765 ≥95%
  • Packaging5mg
  • Price$227
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1137-M010
  • Product descriptionXL765 ≥95%
  • Packaging10mg
  • Price$346
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1137
  • Product descriptionXL765
  • Packaging50mg
  • Price$1065
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1137
  • Product descriptionXL765
  • Packaging100mg
  • Price$1725
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA781923
  • Product descriptionXL765Analogue 98+%
  • Packaging2mg
  • Price$31
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA781923
  • Product descriptionXL765Analogue 98+%
  • Packaging10mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA781923
  • Product descriptionXL765Analogue 98+%
  • Packaging50mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA781923
  • Product descriptionXL765Analogue 98+%
  • Packaging100mg
  • Price$258
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5634
  • Product descriptionSAR245409(XL765)
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5634
  • Product descriptionSAR245409(XL765)
  • Packaging10mM(in 1mL DMSO)
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5634
  • Product descriptionSAR245409(XL765)
  • Packaging25mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5634
  • Product descriptionSAR245409(XL765)
  • Packaging100mg
  • Price$980
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16299
  • Product descriptionXL765 ≥95%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16299
  • Product descriptionXL765 ≥95%
  • Packaging5mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16299
  • Product descriptionXL765 ≥95%
  • Packaging10mg
  • Price$363
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1137-M001 XL765 ≥95% 1mg $135 2021-12-16 Buy
Adipogen Life Sciences SYN-1137-M005 XL765 ≥95% 5mg $227 2021-12-16 Buy
Adipogen Life Sciences SYN-1137-M010 XL765 ≥95% 10mg $346 2021-12-16 Buy
AK Scientific SYN1137 XL765 50mg $1065 2021-12-16 Buy
AK Scientific SYN1137 XL765 100mg $1725 2021-12-16 Buy
Ambeed A781923 XL765Analogue 98+% 2mg $31 2021-12-16 Buy
Ambeed A781923 XL765Analogue 98+% 10mg $68 2021-12-16 Buy
Ambeed A781923 XL765Analogue 98+% 50mg $198 2021-12-16 Buy
Ambeed A781923 XL765Analogue 98+% 100mg $258 2021-12-16 Buy
ApexBio Technology A5634 SAR245409(XL765) 5mg $120 2021-12-16 Buy
ApexBio Technology A5634 SAR245409(XL765) 10mM(in 1mL DMSO) $150 2021-12-16 Buy
ApexBio Technology A5634 SAR245409(XL765) 25mg $350 2021-12-16 Buy
ApexBio Technology A5634 SAR245409(XL765) 100mg $980 2021-12-16 Buy
Cayman Chemical 16299 XL765 ≥95% 1mg $44 2024-03-01 Buy
Cayman Chemical 16299 XL765 ≥95% 5mg $193 2024-03-01 Buy
Cayman Chemical 16299 XL765 ≥95% 10mg $363 2024-03-01 Buy

Properties

Density :1.387±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15 mg/mL in DMSO
form :solid
pka :5.88±0.30(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) constitutively signal and drive cell survival and proliferation in many forms of cancer. XL765 is a dual inhibitor of both PI3K and mTOR, completely blocking phosphorylation of substrates at 8-16 μM. Similarly, XL765 is cytotoxic to glioblastoma multiforme (GBM) xenografts in vitro, with half maximal inhibition occurring at 3.7-7.7 μM. XL765 is orally bioavailable and passes the blood-brain barrier, reducing the growth of intracranial GBM xenografts in mice. This inhibitor is effective alone or in combination therapy with other compounds in various types of cancer.

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