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ChemicalBook >> CAS DataBase List >> XEN445

XEN445

XEN445 price.
  • $32 - $4020
  • Product name: XEN445
  • CAS: 1515856-92-4
  • MF: C18H17F3N2O3
  • MW: 366.33
  • EINECS:
  • MDL Number:MFCD28166367
  • Synonyms:XEN 445, >=98%;XEN445 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid;(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid;2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid XEN445;XEN445;(S)-2-(3-(PYRIDIN-2-YLMETHOXY)PYRROLIDIN-1-YL)-5-(TRIFLUOROMETHYL)BENZOIC ACID. HCL;2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid;2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid
27 prices
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  • Activate Scientific
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Package
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  • 250mg
  • 1g
  • ManufacturerActivate Scientific
  • Product numberAS147382
  • Product descriptionXEN445 98%
  • Packaging250mg
  • Price$563
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5250
  • Product descriptionXEN445
  • Packaging10mg
  • Price$220
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA885460
  • Product descriptionXEN445 98+%
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA885460
  • Product descriptionXEN445 98+%
  • Packaging10mg
  • Price$152
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA885460
  • Product descriptionXEN445 98+%
  • Packaging25mg
  • Price$257
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA885460
  • Product descriptionXEN445 98+%
  • Packaging50mg
  • Price$335
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA885460
  • Product descriptionXEN445 98+%
  • Packaging1g
  • Price$4020
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4663
  • Product descriptionXEN445
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB4663
  • Product descriptionXEN445
  • Packaging10mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4663
  • Product descriptionXEN445
  • Packaging50mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4663
  • Product descriptionXEN445
  • Packaging100mg
  • Price$700
  • Updated2021-12-16
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  • ManufacturerCayman Chemical
  • Product number19144
  • Product descriptionXEN445 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19144
  • Product descriptionXEN445 ≥98%
  • Packaging5mg
  • Price$97
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19144
  • Product descriptionXEN445 ≥98%
  • Packaging10mg
  • Price$184
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM322120
  • Product description(S)-2-(3-(Pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoicacid 98%
  • Packaging100mg
  • Price$497
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003319
  • Product descriptionXEN445 98+%
  • Packaging5mg
  • Price$76
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Activate Scientific AS147382 XEN445 98% 250mg $563 2021-12-16 Buy
AK Scientific SYN5250 XEN445 10mg $220 2021-12-16 Buy
Ambeed A885460 XEN445 98+% 5mg $90 2021-12-16 Buy
Ambeed A885460 XEN445 98+% 10mg $152 2021-12-16 Buy
Ambeed A885460 XEN445 98+% 25mg $257 2021-12-16 Buy
Ambeed A885460 XEN445 98+% 50mg $335 2021-12-16 Buy
Ambeed A885460 XEN445 98+% 1g $4020 2021-12-16 Buy
ApexBio Technology B4663 XEN445 5mg $70 2021-12-16 Buy
ApexBio Technology B4663 XEN445 10mg $130 2021-12-16 Buy
ApexBio Technology B4663 XEN445 50mg $470 2021-12-16 Buy
ApexBio Technology B4663 XEN445 100mg $700 2021-12-16 Buy
Cayman Chemical 19144 XEN445 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 19144 XEN445 ≥98% 5mg $97 2024-03-01 Buy
Cayman Chemical 19144 XEN445 ≥98% 10mg $184 2024-03-01 Buy
Chemenu CM322120 (S)-2-(3-(Pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoicacid 98% 100mg $497 2021-12-16 Buy
Crysdot CD31003319 XEN445 98+% 5mg $76 2021-12-16 Buy

Properties

Boiling point :490.9±45.0 °C(Predicted)
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 14 mg/ml
form :A crystalline solid
pka :3.35±0.36(Predicted)
color :Light brown to brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as a substrate. XEN445 is an endothelial lipase inhibitor (IC50 = 237 nM) that demonstrates selectivity for endothelial lipase compared to lipoprotein and hepatic lipases (IC50s = 20 and 9.5 μM, respectivley). An oral dose of 30 mg/kg XEN445 is reported to increase HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice.

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