WP1066
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- $28 - $1647
- Product name: WP1066
- CAS: 857064-38-1
- MF: C17H14BrN3O
- MW: 356.22
- EINECS:
- MDL Number:MFCD12912450
- Synonyms:WP1066;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide;WP1066/WP-1066;(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP 1066;WP1066, >=99%;wp1066(STAT Inhibitor III);Stat3 Inhibitor III, WP1066
32 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 10mM(in 1mL DMSO)
- 1unit
- 1MG
- 5MG
- 10mg
- 25MG
- 50mg
- 100mg
- 2x50mg
- 250mg
- 500mg
- 1g
- ManufacturerAK Scientific
- Product numberX5924
- Product descriptionWP1066
- Packaging50mg
- Price$252
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001256
- Product descriptionWP1066 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001256
- Product descriptionWP1066 95.00%
- Packaging5MG
- Price$698.02
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001256
- Product descriptionWP1066 95.00%
- Packaging25MG
- Price$1027.8
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4140
- Product descriptionWP1066
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4140
- Product descriptionWP1066
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4140
- Product descriptionWP1066
- Packaging10mM(in 1mL DMSO)
- Price$77
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4140
- Product descriptionWP1066
- Packaging25mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60218
- Product descriptionWP1066 ≥98%
- Packaging10mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2316
- Product descriptionWP1066 99%
- Packaging2x50mg
- Price$484
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB34118
- Product description(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
- Packaging25mg
- Price$72.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB34118
- Product description(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
- Packaging50mg
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB34118
- Product description(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
- Packaging100mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB34118
- Product description(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
- Packaging250mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB34118
- Product description(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
- Packaging500mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14736
- Product descriptionWP1066 ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5924 | WP1066 | 50mg | $252 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001256 | WP1066 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001256 | WP1066 95.00% | 5MG | $698.02 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001256 | WP1066 95.00% | 25MG | $1027.8 | 2021-12-16 | Buy |
| ApexBio Technology | A4140 | WP1066 | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A4140 | WP1066 | 10mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | A4140 | WP1066 | 10mM(in 1mL DMSO) | $77 | 2021-12-16 | Buy |
| ApexBio Technology | A4140 | WP1066 | 25mg | $170 | 2021-12-16 | Buy |
| Arctom | CFN60218 | WP1066 ≥98% | 10mg | $138 | 2021-12-16 | Buy |
| Axon Medchem | Axon2316 | WP1066 99% | 2x50mg | $484 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB34118 | (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide | 25mg | $72.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB34118 | (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide | 50mg | $115 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB34118 | (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide | 100mg | $180 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB34118 | (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide | 250mg | $350 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB34118 | (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide | 500mg | $550 | 2021-12-16 | Buy |
| Cayman Chemical | 14736 | WP1066 ≥95% | 1mg | $32 | 2024-03-01 | Buy |
Properties
Melting point :90-93oC
Boiling point :569.9±50.0 °C(Predicted)
Density :1.425
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Off-white solid
pka :11.00±0.46(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :569.9±50.0 °C(Predicted)
Density :1.425
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Off-white solid
pka :11.00±0.46(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 μM. It also induces apoptosis in U87-MG (IC50 = 5.6 μM) and U373-MG (IC50 = 3.7 μM) cells. WP1066 is orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity, including immune activation as indicated by the up-regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats.More related product prices
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