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ChemicalBook >> CAS DataBase List >> Tipiracil

Tipiracil

Tipiracil price.
  • $5 - $2060
  • Product name: Tipiracil
  • CAS: 183204-72-0
  • MF: C9H12Cl2N4O2
  • MW: 279.12318
  • EINECS:
  • MDL Number:MFCD01571384
  • Synonyms:Tipiracil;Tipiracil (hydrochloride);2,4(1H,3H)-PyriMidinedione,5-chloro-6-[(2-iMino-1-pyrrolidinyl)Methyl] hydrochloride;5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione monohydrochloride;Tipiracil HCl;5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione,hydrochloride;5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione hydrochloride;5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)uracil hydrochloride
39 prices
Selected condition：
Brand
  • AccelPharmtech
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1MG
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 2g
  • 5g
  • 10G
  • 10mM(in 1mL H2O)
  • 25G
  • 100G
  • ManufacturerAccelPharmtech
  • Product numberWW1462
  • Product descriptionTipiracilhydrochloride 99.00%
  • Packaging100G
  • Price$2060
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberWW1462
  • Product descriptionTipiracilhydrochloride 99.00%
  • Packaging25G
  • Price$660
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberWW1462
  • Product descriptionTipiracilhydrochloride 99.00%
  • Packaging10G
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3751BB
  • Product descriptionTipiracilhydrochloride
  • Packaging100mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberHCH0318825
  • Product description5-CHLORO-6-(2-IMINO-PYRROLIDIN-1-YLMETHYL)-1H-PYRIMIDINE-2,4-DIONE HYDROCHLORIDE 95.00%
  • Packaging1MG
  • Price$582.12
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3875
  • Product descriptionTipiracilhydrochloride
  • Packaging5mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3875
  • Product descriptionTipiracilhydrochloride
  • Packaging10mM(in 1mL H2O)
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3875
  • Product descriptionTipiracilhydrochloride
  • Packaging10mg
  • Price$142
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3875
  • Product descriptionTipiracilhydrochloride
  • Packaging25mg
  • Price$271
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3875
  • Product descriptionTipiracilhydrochloride
  • Packaging50mg
  • Price$371
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020122
  • Product description5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98%
  • Packaging5mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020122
  • Product description5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98%
  • Packaging10mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020122
  • Product description5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98%
  • Packaging25mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020122
  • Product description5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98%
  • Packaging50mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020122
  • Product description5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98%
  • Packaging100mg
  • Price$18
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020122
  • Product description5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98%
  • Packaging250mg
  • Price$27
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech WW1462 Tipiracilhydrochloride 99.00% 100G $2060 2021-12-16 Buy
AccelPharmtech WW1462 Tipiracilhydrochloride 99.00% 25G $660 2021-12-16 Buy
AccelPharmtech WW1462 Tipiracilhydrochloride 99.00% 10G $360 2021-12-16 Buy
AK Scientific 3751BB Tipiracilhydrochloride 100mg $77 2021-12-16 Buy
American Custom Chemicals Corporation HCH0318825 5-CHLORO-6-(2-IMINO-PYRROLIDIN-1-YLMETHYL)-1H-PYRIMIDINE-2,4-DIONE HYDROCHLORIDE 95.00% 1MG $582.12 2021-12-16 Buy
ApexBio Technology A3875 Tipiracilhydrochloride 5mg $100 2021-12-16 Buy
ApexBio Technology A3875 Tipiracilhydrochloride 10mM(in 1mL H2O) $105 2021-12-16 Buy
ApexBio Technology A3875 Tipiracilhydrochloride 10mg $142 2021-12-16 Buy
ApexBio Technology A3875 Tipiracilhydrochloride 25mg $271 2021-12-16 Buy
ApexBio Technology A3875 Tipiracilhydrochloride 50mg $371 2021-12-16 Buy
Arctom AS020122 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98% 5mg $5 2021-12-16 Buy
Arctom AS020122 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98% 10mg $6 2021-12-16 Buy
Arctom AS020122 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98% 25mg $8 2021-12-16 Buy
Arctom AS020122 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98% 50mg $10 2021-12-16 Buy
Arctom AS020122 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98% 100mg $18 2021-12-16 Buy
Arctom AS020122 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dionehydrochloride ≥98% 250mg $27 2021-12-16 Buy

Properties

Melting point :245℃ (decomposition)
storage temp. :2-8°C
solubility :DMSO (Slightly, Heated), Water (Slightly)
form :powder
color :white to beige
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Tipiracil (TPI) is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase. It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine , a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.

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