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ChemicalBook >> CAS DataBase List >> TAK-632

TAK-632

TAK-632 price.
  • $28 - $2691.1
  • Product name: TAK-632
  • CAS: 1228591-30-7
  • MF: C27H18F4N4O3S
  • MW: 554.52
  • EINECS:200-256-5
  • MDL Number:MFCD26960965
  • Synonyms:TAK-632;N-(7-CYANO-6-(4-FLUORO-3-(2-(3-(TRIFLUOROMETHYL)PHENYL)ACETAMIDO)PHENOXY)BENZO[D]THIAZOL-2-YL)CYCLOPROPANECARBOXAMIDE;N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide;TAK-0632;N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide TAK632;TAK 632 N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide;TAK-632, >=98%;TAK2 63 (Free base)
30 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
Package
  • 1unit
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1000mg
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1203-M050
  • Product descriptionTAK-632 ≥95%
  • Packaging50mg
  • Price$702
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1203-M100
  • Product descriptionTAK-632 ≥95%
  • Packaging100mg
  • Price$1069
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1203
  • Product descriptionTAK632
  • Packaging5mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8226
  • Product descriptionTAK-632
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8226
  • Product descriptionTAK-632
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8226
  • Product descriptionTAK-632
  • Packaging10mM(in 1mL DMSO)
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8226
  • Product descriptionTAK-632
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8226
  • Product descriptionTAK-632
  • Packaging50mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8226
  • Product descriptionTAK-632
  • Packaging100mg
  • Price$465
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60274
  • Product descriptionTAK-632 ≥98%
  • Packaging10mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181156
  • Product descriptionTAK-632 >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181156
  • Product descriptionTAK-632 >98%
  • Packaging1000mg
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC103614
  • Product descriptionTAK 632
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC103614
  • Product descriptionTAK 632
  • Packaging50mg
  • Price$332.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16285
  • Product descriptionTAK-632 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16285
  • Product descriptionTAK-632 ≥98%
  • Packaging5mg
  • Price$116
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1203-M050 TAK-632 ≥95% 50mg $702 2021-12-16 Buy
Adipogen Life Sciences SYN-1203-M100 TAK-632 ≥95% 100mg $1069 2021-12-16 Buy
AK Scientific SYN1203 TAK632 5mg $140 2021-12-16 Buy
ApexBio Technology A8226 TAK-632 1unit $28 2021-12-16 Buy
ApexBio Technology A8226 TAK-632 5mg $70 2021-12-16 Buy
ApexBio Technology A8226 TAK-632 10mM(in 1mL DMSO) $85 2021-12-16 Buy
ApexBio Technology A8226 TAK-632 10mg $110 2021-12-16 Buy
ApexBio Technology A8226 TAK-632 50mg $300 2021-12-16 Buy
ApexBio Technology A8226 TAK-632 100mg $465 2021-12-16 Buy
Arctom CFN60274 TAK-632 ≥98% 10mg $238 2021-12-16 Buy
Biorbyt Ltd orb181156 TAK-632 >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb181156 TAK-632 >98% 1000mg $2691.1 2021-12-16 Buy
Biosynth Carbosynth FC103614 TAK 632 10mg $95 2021-12-16 Buy
Biosynth Carbosynth FC103614 TAK 632 50mg $332.5 2021-12-16 Buy
Cayman Chemical 16285 TAK-632 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 16285 TAK-632 ≥98% 5mg $116 2024-03-01 Buy

Properties

Density :1.52±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥27.75 mg/mL in DMSO; insoluble in H2O; ≥2.23 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :9.59±0.70(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

TAK-632 is a slow off-rate inhibitor of Raf kinases (IC50s = 8.3, 2.4, and 1.4 nM for wild type B-Raf, mutant B-RafV600E, and c-Raf, respectively). It demonstrates 14-1,200-fold selectivity for Raf over a panel of 26 different kinases. TAK-632 shows significant antiproliferative activity against mutated B-Raf or mutated N-Ras cancer cell lines and xenograft models, inhibiting MEK phosphorylation with an IC50 value of 12 nM and downstream ERK phosphorylation with an IC50 value of 16 nM.

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