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ChemicalBook >> CAS DataBase List >> (S)-CR8

(S)-CR8

(S)-CR8 price.
  • $44 - $479
  • Product name: (S)-CR8
  • CAS: 1084893-56-0
  • MF: C24H29N7O
  • MW: 431.53
  • EINECS:
  • MDL Number:MFCD23160354
  • Synonyms:CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem;1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-;CR8, (S)-Isomer;(S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor
5 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-MR-C0004-M010
  • Product description(S)-CR8 ≥99%(NMR)
  • Packaging10mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29985
  • Product description(S)-CR8
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29985
  • Product description(S)-CR8
  • Packaging5mg
  • Price$183
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29985
  • Product description(S)-CR8
  • Packaging10mg
  • Price$278
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29985
  • Product description(S)-CR8
  • Packaging25mg
  • Price$479
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-MR-C0004-M010 (S)-CR8 ≥99%(NMR) 10mg $200 2021-12-16 Buy
Cayman Chemical 29985 (S)-CR8 1mg $44 2024-03-01 Buy
Cayman Chemical 29985 (S)-CR8 5mg $183 2024-03-01 Buy
Cayman Chemical 29985 (S)-CR8 10mg $278 2024-03-01 Buy
Cayman Chemical 29985 (S)-CR8 25mg $479 2024-03-01 Buy

Properties

Boiling point :671.4±65.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO: soluble,Ethanol: soluble
form :Off-white solid
pka :14.56±0.10(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.

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