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ChemicalBook >> CAS DataBase List >> QUINOMYCIN A

QUINOMYCIN A

QUINOMYCIN A price.
  • $97 - $1365
  • Product name: QUINOMYCIN A
  • CAS: 512-64-1
  • MF: C51H64N12O12S2
  • MW: 1101.26
  • EINECS:
  • MDL Number:MFCD00156105
  • Synonyms:echinomycina ;nsc526417 ;ECHINOMYCIN;N-[(1R,4S,8R,11S,14R,17S,21R,24S)-3,11,13,16,24,26-hexamethyl-27-methylsulfanyl-2,5,9,12,15,18,22,25-octaoxo-4,17-di(propan-2-yl)-8-(quinoxaline-2-carbonylamino)-6,19-dioxa-28-thia-3,10,13,16,23,26-hexazabicyclo[12.12.3]nonacosan-21-yl]quinoxaline-2-carbo;N-(2-Quinoxalinylcarbonyl)cyclo(D-Ser*-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-N-(quinoxaline-2-ylcarbonyl)-D-Ser*-Ala-N-methyl-3-methylthio-L-Ala(1)-N-methyl-L-Val-);SK-302B;Echinomycin >97%;N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl L-valine (81)-lactone cyclic (37)-thioester
11 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 1
  • 1MG
  • 2.5mg
  • 5mg
  • ManufacturerAdipogen Life Sciences
  • Product numberBVT-0267-M005
  • Product descriptionEchinomycin ≥98%(HPLC)
  • Packaging5mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2677AH
  • Product descriptionQuinomycinA
  • Packaging5mg
  • Price$473
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0010197
  • Product descriptionQUINOMYCIN A 95.00%
  • Packaging1MG
  • Price$1365
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11049
  • Product descriptionEchinomycin ≥98%
  • Packaging1mg
  • Price$97
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11049
  • Product descriptionEchinomycin ≥98%
  • Packaging5mg
  • Price$360
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0024860
  • Product descriptionEchinomycin ≥98.0%
  • Packaging1mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0477
  • Product descriptionEchinomycin ≥98% (HPLC)
  • Packaging5mg
  • Price$588
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0477
  • Product descriptionEchinomycin ≥98% (HPLC)
  • Packaging1mg
  • Price$142
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number5520
  • Product descriptionEchinomycin ≥98%(HPLC)
  • Packaging1
  • Price$118
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberQ765503
  • Product descriptionQuinomycinA
  • Packaging2.5mg
  • Price$545
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product numberQ1101
  • Product descriptionQuinomycin A
  • Packaging1mg
  • Price$339
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences BVT-0267-M005 Echinomycin ≥98%(HPLC) 5mg $300 2021-12-16 Buy
AK Scientific 2677AH QuinomycinA 5mg $473 2021-12-16 Buy
American Custom Chemicals Corporation API0010197 QUINOMYCIN A 95.00% 1MG $1365 2021-12-16 Buy
Cayman Chemical 11049 Echinomycin ≥98% 1mg $97 2024-03-01 Buy
Cayman Chemical 11049 Echinomycin ≥98% 5mg $360 2024-03-01 Buy
ChemScene CS-0024860 Echinomycin ≥98.0% 1mg $250 2021-12-16 Buy
Sigma-Aldrich SML0477 Echinomycin ≥98% (HPLC) 5mg $588 2024-03-01 Buy
Sigma-Aldrich SML0477 Echinomycin ≥98% (HPLC) 1mg $142 2024-03-01 Buy
Tocris 5520 Echinomycin ≥98%(HPLC) 1 $118 2021-12-16 Buy
TRC Q765503 QuinomycinA 2.5mg $545 2021-12-16 Buy
Usbiological Q1101 Quinomycin A 1mg $339 2021-12-16 Buy

Properties

Melting point :217-218℃
alpha :D20 -310° (c = 0.86 in chloroform)
Boiling point :1427.2±65.0 °C(Predicted)
Density :1.0964 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :9.38±0.70(Predicted)
form :White solid
color :white to beige
Merck :13,3531
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription. It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the hypoxia-responsive element. Echinomycin reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50 value of 1.2 nM. It inhibits hypoxia-induced expression of vascular endothelial growth factor, blocking angiogenesis and altering excitatory synaptic transmission in hippocampal neurons. Echinomycin also impairs expression of survivin, enhancing the sensitivity of multiple myeloma cells to melphalan.

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