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ChemicalBook >> CAS DataBase List >> Pimecrolimus

Pimecrolimus

Pimecrolimus price.
  • $15 - $4030.95
  • Product name: Pimecrolimus
  • CAS: 137071-32-0
  • MF: C43H68ClNO11
  • MW: 810.45
  • EINECS:603-999-7
  • MDL Number:MFCD00901792
  • Synonyms:ASM 981;SDZ-ASM 981;Picrolimus;Pimecrolimus;15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26as)-;15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-(2-(4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S-(3R*(E(1S*,3S*,4R*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26ar*))-;Unii-7kyv510875;PiMecroliMus(Elidel, SDZ-ASM-981)
25 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Cayman Chemical
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-P0598-M010
  • Product descriptionPimecrolimus ≥97%(HPLC)
  • Packaging10mg
  • Price$24
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7261
  • Product descriptionPimecrolimus
  • Packaging50mg
  • Price$153
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA944531
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging1mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA944531
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging5mg
  • Price$35
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA944531
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging10mg
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA944531
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging25mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA944531
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging50mg
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA944531
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging100mg
  • Price$177
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000595
  • Product descriptionPIMECROLIMUS 95.00%
  • Packaging10MG
  • Price$130.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000595
  • Product descriptionPIMECROLIMUS 95.00%
  • Packaging1G
  • Price$4030.95
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFE27046
  • Product descriptionPimecrolimus
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFE27046
  • Product descriptionPimecrolimus
  • Packaging50mg
  • Price$263
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13107
  • Product descriptionPimecrolimus ≥98%
  • Packaging10mg
  • Price$26
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13107
  • Product descriptionPimecrolimus ≥98%
  • Packaging50mg
  • Price$111
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13107
  • Product descriptionPimecrolimus ≥98%
  • Packaging100mg
  • Price$195
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003714
  • Product descriptionPimecrolimus(Elidel) 98+%
  • Packaging100mg
  • Price$157
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-P0598-M010 Pimecrolimus ≥97%(HPLC) 10mg $24 2021-12-16 Buy
AK Scientific X7261 Pimecrolimus 50mg $153 2021-12-16 Buy
Ambeed A944531 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 1mg $15 2021-12-16 Buy
Ambeed A944531 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 5mg $35 2021-12-16 Buy
Ambeed A944531 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 10mg $52 2021-12-16 Buy
Ambeed A944531 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 25mg $77 2021-12-16 Buy
Ambeed A944531 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 50mg $115 2021-12-16 Buy
Ambeed A944531 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 100mg $177 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000595 PIMECROLIMUS 95.00% 10MG $130.2 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000595 PIMECROLIMUS 95.00% 1G $4030.95 2021-12-16 Buy
Biosynth Carbosynth FE27046 Pimecrolimus 10mg $75 2021-12-16 Buy
Biosynth Carbosynth FE27046 Pimecrolimus 50mg $263 2021-12-16 Buy
Cayman Chemical 13107 Pimecrolimus ≥98% 10mg $26 2024-03-01 Buy
Cayman Chemical 13107 Pimecrolimus ≥98% 50mg $111 2024-03-01 Buy
Cayman Chemical 13107 Pimecrolimus ≥98% 100mg $195 2024-03-01 Buy
Crysdot CD31003714 Pimecrolimus(Elidel) 98+% 100mg $157 2021-12-16 Buy

Properties

Melting point :135-136 °C
Boiling point :866.1±75.0 °C(Predicted)
Density :1.19
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO (Slightly, Sonicated), Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :9.97±0.70(Predicted)
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P322 Specific measures (see …on this label).
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase). Presumably through these actions, it blocks the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) without affecting dendritic cells. Moreover, pimecrolimus suppresses the generation of pro-inflammatory cytokines by T cells, the release of pre-formed inflammatory mediators from mast cells, and the activation of eosinophils. These effects support the use of pimecrolimus in countering inflammatory skin diseases, such as atopic dermatitis (eczema) and psoriasis.

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