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ChemicalBook >> CAS DataBase List >> PF-01247324

PF-01247324

PF-01247324 price.
  • $33 - $900
  • Product name: PF-01247324
  • CAS: 875051-72-2
  • MF: C13H10Cl3N3O
  • MW: 330.6
  • EINECS:
  • MDL Number:MFCD28156579
  • Synonyms:2-PyridinecarboxaMide, 6-aMino-N-Methyl-5-(2,3,5-trichlorophenyl)-;6-amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamide;6-AMINO-5-(2,3,5-TRICHLORO-PHENYL)-PYRIDINE-2-CARBOXYLIC ACID METHYLAMIDE;PF-1247324;PF-01247324;6-AMINO-N-METHYL-5-(2,3,5-TRICHLOROPHENYL)PYRIDINE-2-CARBOXAMIDE;PF01247324;PF 01247324;133786
14 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number9712CS
  • Product description6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide
  • Packaging10mg
  • Price$293
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22111
  • Product descriptionPF-01247324 ≥98%
  • Packaging1mg
  • Price$33
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22111
  • Product descriptionPF-01247324 ≥98%
  • Packaging5mg
  • Price$96
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22111
  • Product descriptionPF-01247324 ≥98%
  • Packaging10mg
  • Price$176
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22111
  • Product descriptionPF-01247324 ≥98%
  • Packaging25mg
  • Price$396
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6331
  • Product descriptionPF-01247324 99.73%
  • Packaging5mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6331
  • Product descriptionPF-01247324 99.73%
  • Packaging10mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6331
  • Product descriptionPF-01247324 99.73%
  • Packaging25mg
  • Price$312
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6331
  • Product descriptionPF-01247324 99.73%
  • Packaging50mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6331
  • Product descriptionPF-01247324 99.73%
  • Packaging100mg
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10038
  • Product descriptionPF-01247324 >98%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPZ0274
  • Product descriptionPF-01247324 ≥98% (HPLC)
  • Packaging5MG
  • Price$115
  • Updated2023-06-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPZ0274
  • Product descriptionPF-01247324 ≥98% (HPLC)
  • Packaging25MG
  • Price$451
  • Updated2023-06-20
  • Buy
  • ManufacturerTRC
  • Product numberA634545
  • Product description6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamide
  • Packaging1mg
  • Price$70
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9712CS 6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide 10mg $293 2021-12-16 Buy
Cayman Chemical 22111 PF-01247324 ≥98% 1mg $33 2024-03-01 Buy
Cayman Chemical 22111 PF-01247324 ≥98% 5mg $96 2024-03-01 Buy
Cayman Chemical 22111 PF-01247324 ≥98% 10mg $176 2024-03-01 Buy
Cayman Chemical 22111 PF-01247324 ≥98% 25mg $396 2024-03-01 Buy
ChemScene CS-6331 PF-01247324 99.73% 5mg $84 2021-12-16 Buy
ChemScene CS-6331 PF-01247324 99.73% 10mg $144 2021-12-16 Buy
ChemScene CS-6331 PF-01247324 99.73% 25mg $312 2021-12-16 Buy
ChemScene CS-6331 PF-01247324 99.73% 50mg $540 2021-12-16 Buy
ChemScene CS-6331 PF-01247324 99.73% 100mg $900 2021-12-16 Buy
DC Chemicals DC10038 PF-01247324 >98% 100mg $450 2021-12-16 Buy
Sigma-Aldrich PZ0274 PF-01247324 ≥98% (HPLC) 5MG $115 2023-06-20 Buy
Sigma-Aldrich PZ0274 PF-01247324 ≥98% (HPLC) 25MG $451 2023-06-20 Buy
TRC A634545 6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamide 1mg $70 2021-12-16 Buy

Properties

Boiling point :477.7±45.0 °C(Predicted)
Density :1.460±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
pka :6.56±0.46(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PF-01247324 is a blocker of the tetrodotoxin-resistant (TTX-R) sodium channel Nav1.8 (IC50 = 0.19 μM for human Nav1.8). It is selective for Nav1.8 over Nav1.1, Nav1.2, Nav1.5, and Nav1.7 channels (IC50s = 13, 12.8, 9, and 19 μM, respectively) as well as ether-a-go-go (ERG) potassium channels (IC50 = 30 μM). PF-01247324 blocks Nav1.8 channels in a VSP-FRET assay using HEK293 cells (IC50 = 2.6 μM). In vivo, PF-01247324 (100 mg/kg) reduces phase 2 flinching in a rat model of formalin-induced persistent pain. It increases latency to lift the inflamed paw and latency to paw withdrawal in rat models of carrageenan-induced thermal hyperalgesia and mechanical hyperalgesia induced by complete Freund''s adjuvant (CFA), respectively.

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