PD 146176
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- $45 - $2282
- Product name: PD 146176
- CAS: 4079-26-9
- MF: C15H11NS
- MW: 237.32
- EINECS:
- MDL Number:MFCD05664738
- Synonyms:6,11-dihydrothiochromeno[4,3-b]indole;[1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-;PD146176 (NSC168807);NSC168807;inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reticulocyte,impairment,cognitive,mice,NSC 168807,Inhibitor,cells,PD 146176,IC21,PD-146176,rabbit,Ferroptosis;PD 146176
18 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Cayman Chemical
- CSNpharm
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number8594CB
- Product description6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
- Packaging10mg
- Price$197
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA945188
- Product descriptionPD 146176 98%
- Packaging5mg
- Price$69
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA945188
- Product descriptionPD 146176 98%
- Packaging10mg
- Price$117
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA945188
- Product descriptionPD 146176 98%
- Packaging25mg
- Price$258
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA945188
- Product descriptionPD 146176 98%
- Packaging50mg
- Price$440
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA945188
- Product descriptionPD 146176 98%
- Packaging100mg
- Price$634
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA945188
- Product descriptionPD 146176 98%
- Packaging250mg
- Price$911
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA945188
- Product descriptionPD 146176 98%
- Packaging1g
- Price$2282
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7208
- Product descriptionPD 146176
- Packaging5mg
- Price$551
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10010518
- Product descriptionPD 146176 ≥98%
- Packaging5mg
- Price$48
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10010518
- Product descriptionPD 146176 ≥98%
- Packaging10mg
- Price$89
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10010518
- Product descriptionPD 146176 ≥98%
- Packaging25mg
- Price$210
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10010518
- Product descriptionPD 146176 ≥98%
- Packaging50mg
- Price$371
- Updated2024-03-01
- Buy
- ManufacturerCSNpharm
- Product numberCSN23023
- Product descriptionPD 146176
- Packaging5mg
- Price$76
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN23023
- Product descriptionPD 146176
- Packaging1mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberP4620
- Product descriptionPD 146176 ≥98% (HPLC), solid
- Packaging25mg
- Price$636
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8594CB | 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole | 10mg | $197 | 2021-12-16 | Buy |
| Ambeed | A945188 | PD 146176 98% | 5mg | $69 | 2021-12-16 | Buy |
| Ambeed | A945188 | PD 146176 98% | 10mg | $117 | 2021-12-16 | Buy |
| Ambeed | A945188 | PD 146176 98% | 25mg | $258 | 2021-12-16 | Buy |
| Ambeed | A945188 | PD 146176 98% | 50mg | $440 | 2021-12-16 | Buy |
| Ambeed | A945188 | PD 146176 98% | 100mg | $634 | 2021-12-16 | Buy |
| Ambeed | A945188 | PD 146176 98% | 250mg | $911 | 2021-12-16 | Buy |
| Ambeed | A945188 | PD 146176 98% | 1g | $2282 | 2021-12-16 | Buy |
| ApexBio Technology | B7208 | PD 146176 | 5mg | $551 | 2021-12-16 | Buy |
| Cayman Chemical | 10010518 | PD 146176 ≥98% | 5mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 10010518 | PD 146176 ≥98% | 10mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 10010518 | PD 146176 ≥98% | 25mg | $210 | 2024-03-01 | Buy |
| Cayman Chemical | 10010518 | PD 146176 ≥98% | 50mg | $371 | 2024-03-01 | Buy |
| CSNpharm | CSN23023 | PD 146176 | 5mg | $76 | 2021-12-16 | Buy |
| CSNpharm | CSN23023 | PD 146176 | 1mg | $45 | 2021-12-16 | Buy |
| Sigma-Aldrich | P4620 | PD 146176 ≥98% (HPLC), solid | 25mg | $636 | 2024-03-01 | Buy |
Properties
Melting point :160 °C
Boiling point :485.4±24.0 °C(Predicted)
Density :1.333±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :DMSO: 16 mg/mL, soluble
form :solid
pka :16.17±0.20(Predicted)
color :cream-colored
Boiling point :485.4±24.0 °C(Predicted)
Density :1.333±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :DMSO: 16 mg/mL, soluble
form :solid
pka :16.17±0.20(Predicted)
color :cream-colored
Safety Information
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Description
PD-146176 is a potent and selective inhibitor of 15-LO that suppresses oxidant stress-induced apoptosis in endothelial cells. Studies indicate that PD-146176 reduces atherosclerotic lesion development in New Zealand white rabbit through its nonspecific antioxidant properties. It is known that PD-146176 acts as a noncompetitive inhibitor towards 15-LO, displaying a Ki=197 nM. Furthermore, PD-146176 reduces monocyte macrophage enrichment of atherosclerotic lesions and development of fibrofoamy and fibrous plaque.More related product prices
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![6,11-Dihydrothiochromeno[4,3-b]indole](https://img.chemicalbook.com/ProductImageEN/2019-12/small/b20434cc-b711-4793-a491-5566cea1c3c5.png){kind=small}