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ChemicalBook >> CAS DataBase List >> MPI-0479605

MPI-0479605

MPI-0479605 price.
  • $57 - $2095
  • Product name: MPI-0479605
  • CAS: 1246529-32-7
  • MF: C22H29N7O
  • MW: 407.51
  • EINECS:
  • MDL Number:MFCD28099811
  • Synonyms:MPI-0479605;N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine;MPI0479605 HCl;N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine;MPI-0479605;MPI 0479605;MPI0479605;9H-?Purine-?2,?6-?diamine, N6-?cyclohexyl-?N2-?[2-?methyl-?4-?(4-?morpholinyl)?phenyl]?-;CS-1459;MPI-0479605 USP/EP/BP
21 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1187-M001
  • Product descriptionMPI-0479605hydrochloride ≥95%
  • Packaging1mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1187-M005
  • Product descriptionMPI-0479605hydrochloride ≥95%
  • Packaging5mg
  • Price$346
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2574AH
  • Product descriptionN6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine
  • Packaging1g
  • Price$1246
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3706
  • Product descriptionMPI-0479605
  • Packaging2mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3706
  • Product descriptionMPI-0479605
  • Packaging5mg
  • Price$331
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3706
  • Product descriptionMPI-0479605
  • Packaging10mg
  • Price$612
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3706
  • Product descriptionMPI-0479605
  • Packaging50mg
  • Price$2095
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181294
  • Product descriptionMPI-0479605 >98%
  • Packaging250mg
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22136
  • Product descriptionMPI-0479605 ≥98%
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22136
  • Product descriptionMPI-0479605 ≥98%
  • Packaging5mg
  • Price$233
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22136
  • Product descriptionMPI-0479605 ≥98%
  • Packaging10mg
  • Price$437
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22136
  • Product descriptionMPI-0479605 ≥98%
  • Packaging25mg
  • Price$957
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM138767
  • Product descriptionN6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine 98%
  • Packaging10mg
  • Price$249
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM138767
  • Product descriptionN6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine 98%
  • Packaging50mg
  • Price$870
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4665
  • Product descriptionMPI-0479605 99.13%
  • Packaging5mg
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4665
  • Product descriptionMPI-0479605 99.13%
  • Packaging10mg
  • Price$456
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1187-M001 MPI-0479605hydrochloride ≥95% 1mg $205 2021-12-16 Buy
Adipogen Life Sciences SYN-1187-M005 MPI-0479605hydrochloride ≥95% 5mg $346 2021-12-16 Buy
AK Scientific 2574AH N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine 1g $1246 2021-12-16 Buy
ApexBio Technology B3706 MPI-0479605 2mg $205 2021-12-16 Buy
ApexBio Technology B3706 MPI-0479605 5mg $331 2021-12-16 Buy
ApexBio Technology B3706 MPI-0479605 10mg $612 2021-12-16 Buy
ApexBio Technology B3706 MPI-0479605 50mg $2095 2021-12-16 Buy
Biorbyt Ltd orb181294 MPI-0479605 >98% 250mg $1504.5 2021-12-16 Buy
Cayman Chemical 22136 MPI-0479605 ≥98% 1mg $57 2024-03-01 Buy
Cayman Chemical 22136 MPI-0479605 ≥98% 5mg $233 2024-03-01 Buy
Cayman Chemical 22136 MPI-0479605 ≥98% 10mg $437 2024-03-01 Buy
Cayman Chemical 22136 MPI-0479605 ≥98% 25mg $957 2024-03-01 Buy
Chemenu CM138767 N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine 98% 10mg $249 2021-12-16 Buy
Chemenu CM138767 N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine 98% 50mg $870 2021-12-16 Buy
ChemScene CS-4665 MPI-0479605 99.13% 5mg $252 2021-12-16 Buy
ChemScene CS-4665 MPI-0479605 99.13% 10mg $456 2021-12-16 Buy

Properties

Boiling point :745.8±70.0 °C(Predicted)
Density :1.318±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO
form :A crystalline solid
pka :10.52±0.10(Predicted)
color :White to gray

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Description

MPI-0479605 is a potent and ATP-competitive inhibitor of the mitotic kinase MPS1 (IC50 = 1.8 nM). It is selective for MPS1 over a panel of 79 kinases at a concentration of 500 nM. MPI-0479605 induces time-dependent degradation of cyclin B and securin and decreases phosphorylation of BUBR1 resulting in failed cytokinesis in HeLa cells arrested by nocodazole . It also causes misalignment of chromosomes at the anaphase plate and aneuploidy in A549 cells and slows cell cycle progression of HCT116 and COLO 205 cells irrespective of p53 activity. MPI-0479605 (30-150 mg/kg) reduces tumor volume in an HCT116 mouse colon cancer xenograft model in a dose-dependent manner.

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