MIF Antagonist, ISO-1
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- $32 - $3475
- Product name: MIF Antagonist, ISO-1
- CAS: 478336-92-4
- MF: C12H13NO4
- MW: 235.24
- EINECS:-0
- MDL Number:MFCD22376813
- Synonyms:MIF Antagonist, ISO-1;Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate;ISO-1;MIF Antagonist;4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester;ISO-1 (ISO 1;ISO 1;ISO1;MIF ANTAGONIST;5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester
30 prices
Selected condition：
Brand
- AK Scientific
- Alfa Aesar
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- Chem-Impex
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 1MG
- 5mg
- 10mg
- 25mg
- 50
- 50mg
- 250mg
- 10
- 5g
- ManufacturerAK Scientific
- Product number6540AB
- Product descriptionMethyl2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate
- Packaging5g
- Price$2500
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ64947
- Product descriptionMIF Antagonist, ISO-1
- Packaging5mg
- Price$114
- Updated2023-06-20
- Buy
- ManufacturerAlfa Aesar
- Product numberJ64947
- Product descriptionMIF Antagonist, ISO-1
- Packaging25mg
- Price$442
- Updated2023-06-20
- Buy
- ManufacturerAmbeed
- Product numberA128540
- Product descriptionISO-1 98+%
- Packaging5mg
- Price$89
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA128540
- Product descriptionISO-1 98+%
- Packaging10mg
- Price$151
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA128540
- Product descriptionISO-1 98+%
- Packaging25mg
- Price$256
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA128540
- Product descriptionISO-1 98+%
- Packaging50mg
- Price$333
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0002669
- Product descriptionMETHYL-2-(3-(4-HYDROXYPHENYL)-4,5-DIHYDROISOXAZOL-5-YL)ACETATE 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0002669
- Product descriptionMETHYL-2-(3-(4-HYDROXYPHENYL)-4,5-DIHYDROISOXAZOL-5-YL)ACETATE 95.00%
- Packaging5MG
- Price$504.96
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4714
- Product descriptionISO-1
- Packaging10mg
- Price$221
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611732
- Product descriptionISO-1
- Packaging10mg
- Price$306
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611732
- Product descriptionISO-1
- Packaging50mg
- Price$720.8
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14929
- Product descriptionMIF Antagonist ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14929
- Product descriptionMIF Antagonist ≥95%
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM191379
- Product descriptionMethyl2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate 98%
- Packaging50mg
- Price$385
- Updated2021-12-16
- Buy
- ManufacturerChem-Impex
- Product number42225
- Product descriptionISO-1,98%(HPLC) 98%(HPLC)
- Packaging5MG
- Price$98.56
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 6540AB | Methyl2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate | 5g | $2500 | 2021-12-16 | Buy |
| Alfa Aesar | J64947 | MIF Antagonist, ISO-1 | 5mg | $114 | 2023-06-20 | Buy |
| Alfa Aesar | J64947 | MIF Antagonist, ISO-1 | 25mg | $442 | 2023-06-20 | Buy |
| Ambeed | A128540 | ISO-1 98+% | 5mg | $89 | 2021-12-16 | Buy |
| Ambeed | A128540 | ISO-1 98+% | 10mg | $151 | 2021-12-16 | Buy |
| Ambeed | A128540 | ISO-1 98+% | 25mg | $256 | 2021-12-16 | Buy |
| Ambeed | A128540 | ISO-1 98+% | 50mg | $333 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0002669 | METHYL-2-(3-(4-HYDROXYPHENYL)-4,5-DIHYDROISOXAZOL-5-YL)ACETATE 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0002669 | METHYL-2-(3-(4-HYDROXYPHENYL)-4,5-DIHYDROISOXAZOL-5-YL)ACETATE 95.00% | 5MG | $504.96 | 2021-12-16 | Buy |
| ApexBio Technology | B4714 | ISO-1 | 10mg | $221 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611732 | ISO-1 | 10mg | $306 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611732 | ISO-1 | 50mg | $720.8 | 2021-12-16 | Buy |
| Cayman Chemical | 14929 | MIF Antagonist ≥95% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 14929 | MIF Antagonist ≥95% | 5mg | $116 | 2024-03-01 | Buy |
| Chemenu | CM191379 | Methyl2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate 98% | 50mg | $385 | 2021-12-16 | Buy |
| Chem-Impex | 42225 | ISO-1,98%(HPLC) 98%(HPLC) | 5MG | $98.56 | 2021-12-16 | Buy |
Properties
Melting point :114 °C
Boiling point :365.0±48.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO.
pka :9.22±0.30(Predicted)
form :Light yellow crystalline solid.
color :Off-white
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Boiling point :365.0±48.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO.
pka :9.22±0.30(Predicted)
form :Light yellow crystalline solid.
color :Off-white
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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Description
Macrophage migration inhibitory factor (MIF) is a regulator of inflammation that also has roles in cancer and autoimmune diseases. MIF exhibits both tautomerase and oxidoreductase activities, although how these are linked to MIF’s physiological and pathophysiological actions is unclear. MIF antagonist, also known as ISO-1, is an inhibitor of the dopachrome tautomerase activity of MIF in vitro (IC50 = 7 μM) and in cells (IC50 = 25 μM). It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and improves the survival of mice following sepsis. MIF antagonist also demonstrates protective effects in airway and gastrointestinal inflammation in mice.More related product prices
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