LB 42708
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- $40 - $2691.1
- Product name: LB 42708
- CAS: 226929-39-1
- MF: C30H27BrN4O2
- MW: 555.47
- EINECS:
- MDL Number:MFCD20926350
- Synonyms:LB 42708;[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinylmethanone;[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinylmethanone LB42708;4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine;[1-{[1-(4-bromobenzyl)-1h-imidazol-5-yl]methyl}-4-(1-naphthyl)-1h -pyrrol-3-yl](4-morpholinyl)methanone;LB-42708;LB 42708;CS-1450;Methanone, [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-
24 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 2x25mg
- 50MG
- 100mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- 1000mg
- ManufacturerAK Scientific
- Product number2507AH
- Product description(1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone
- Packaging1mg
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2507AH
- Product description(1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone
- Packaging5mg
- Price$229
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2507AH
- Product description(1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone
- Packaging10mg
- Price$313
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001275
- Product description[1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00%
- Packaging50MG
- Price$1050
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001275
- Product description[1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00%
- Packaging10MG
- Price$545
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001275
- Product description[1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00%
- Packaging5MG
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3703
- Product descriptionLB42708
- Packaging5mg
- Price$74
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3703
- Product descriptionLB42708
- Packaging10mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3703
- Product descriptionLB42708
- Packaging10mM(in 1mL DMSO)
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1794
- Product descriptionLB42708 99%
- Packaging2x25mg
- Price$638
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181275
- Product descriptionLB42708 >98%
- Packaging100mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181275
- Product descriptionLB42708 >98%
- Packaging250mg
- Price$1431.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181275
- Product descriptionLB42708 >98%
- Packaging1000mg
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16428
- Product descriptionLB 42708 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16428
- Product descriptionLB 42708 ≥98%
- Packaging5mg
- Price$118
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16428
- Product descriptionLB 42708 ≥98%
- Packaging10mg
- Price$193
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2507AH | (1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone | 1mg | $147 | 2021-12-16 | Buy |
| AK Scientific | 2507AH | (1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone | 5mg | $229 | 2021-12-16 | Buy |
| AK Scientific | 2507AH | (1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone | 10mg | $313 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001275 | [1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00% | 50MG | $1050 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001275 | [1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00% | 10MG | $545 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001275 | [1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00% | 5MG | $480 | 2021-12-16 | Buy |
| ApexBio Technology | B3703 | LB42708 | 5mg | $74 | 2021-12-16 | Buy |
| ApexBio Technology | B3703 | LB42708 | 10mg | $119 | 2021-12-16 | Buy |
| ApexBio Technology | B3703 | LB42708 | 10mM(in 1mL DMSO) | $170 | 2021-12-16 | Buy |
| Axon Medchem | Axon1794 | LB42708 99% | 2x25mg | $638 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181275 | LB42708 >98% | 100mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181275 | LB42708 >98% | 250mg | $1431.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181275 | LB42708 >98% | 1000mg | $2691.1 | 2021-12-16 | Buy |
| Cayman Chemical | 16428 | LB 42708 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16428 | LB 42708 ≥98% | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 16428 | LB 42708 ≥98% | 10mg | $193 | 2024-03-01 | Buy |
Properties
Boiling point :769.6±60.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥22.75 mg/mL in DMSO; insoluble in H2O; ≥47.5 mg/mL in EtOH
pka :5.67±0.13(Predicted)
form :solid
color :Off-white to light yellow
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥22.75 mg/mL in DMSO; insoluble in H2O; ≥47.5 mg/mL in EtOH
pka :5.67±0.13(Predicted)
form :solid
color :Off-white to light yellow
Safety Information
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Description
Farnesylation, the post-translational addition of a 15-carbon isoprenyl group, alters the function of several proteins, including Ras proteins. LB 42708 is a potent inhibitor of farnesyltransferase (FTase), blocking farnesylation of H-Ras, N-Ras, and K-Ras4B with IC50 values of 0.8, 1.2, and 2.0 nM, respectively. It displays over 50,000-fold selectivity for FTase over geranylgeranyltransferase I. LB 42708 prevents the farnesylation of H-Ras in response to LPS plus IFN-γ (IC50 = 10 nM), preventing activation of NF-κB as well as downstream signaling. These effects are obtained both in RAW 264.7 mouse macrophages and in mice. LB42708 also inhibits Ras-dependent signaling in endothelial cells, stopping VEGF-mediated angiogenesis both in vitro and in vivo.Related product price
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