IM-12
|
- $32 - $1800
- Product name: IM-12
- CAS: 1129669-05-1
- MF: C22H20FN3O2
- MW: 377.41
- EINECS:
- MDL Number:MFCD20527313
- Synonyms:IM-12;3-(4-fluorophenethylaMino)-1-Methyl-4-(2-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione IM-12;3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;CS-1819;CS-2144;The GSK3β Inhibitor XIX
22 prices
Selected condition：
Brand
- Alichem
- Ambeed
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- ManufacturerAlichem
- Product number1129669051
- Product description3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- Packaging250mg
- Price$714
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1129669051
- Product description3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- Packaging500mg
- Price$1029
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1129669051
- Product description3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- Packaging1g
- Price$1651.3
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA235864
- Product descriptionIM-12 98+%
- Packaging5mg
- Price$128
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA235864
- Product descriptionIM-12 98+%
- Packaging10mg
- Price$166
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA235864
- Product descriptionIM-12 98+%
- Packaging50mg
- Price$279
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA235864
- Product descriptionIM-12 98+%
- Packaging100mg
- Price$362
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4793
- Product descriptionIM-12
- Packaging50mg
- Price$264
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2511
- Product descriptionIM12 99%
- Packaging50mg
- Price$374
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17673
- Product descriptionIM-12 ≥98%
- Packaging25mg
- Price$230
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17673
- Product descriptionIM-12 ≥98%
- Packaging10mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17673
- Product descriptionIM-12 ≥98%
- Packaging5mg
- Price$70
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17673
- Product descriptionIM-12 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM148911
- Product description3-((4-fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 95%+
- Packaging100mg
- Price$456
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3399
- Product descriptionIM-12 98.30%
- Packaging10mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3399
- Product descriptionIM-12 98.30%
- Packaging50mg
- Price$362
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Alichem | 1129669051 | 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | 250mg | $714 | 2021-12-16 | Buy |
| Alichem | 1129669051 | 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | 500mg | $1029 | 2021-12-16 | Buy |
| Alichem | 1129669051 | 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | 1g | $1651.3 | 2021-12-16 | Buy |
| Ambeed | A235864 | IM-12 98+% | 5mg | $128 | 2021-12-16 | Buy |
| Ambeed | A235864 | IM-12 98+% | 10mg | $166 | 2021-12-16 | Buy |
| Ambeed | A235864 | IM-12 98+% | 50mg | $279 | 2021-12-16 | Buy |
| Ambeed | A235864 | IM-12 98+% | 100mg | $362 | 2021-12-16 | Buy |
| ApexBio Technology | B4793 | IM-12 | 50mg | $264 | 2021-12-16 | Buy |
| Axon Medchem | Axon2511 | IM12 99% | 50mg | $374 | 2021-12-16 | Buy |
| Cayman Chemical | 17673 | IM-12 ≥98% | 25mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 17673 | IM-12 ≥98% | 10mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 17673 | IM-12 ≥98% | 5mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 17673 | IM-12 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Chemenu | CM148911 | 3-((4-fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 95%+ | 100mg | $456 | 2021-12-16 | Buy |
| ChemScene | CS-3399 | IM-12 98.30% | 10mg | $98 | 2021-12-16 | Buy |
| ChemScene | CS-3399 | IM-12 98.30% | 50mg | $362 | 2021-12-16 | Buy |
Properties
Melting point :187 °C
Boiling point :600.2±55.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥9mg/mL
form :powder
pka :16.77±0.30(Predicted)
color :yellow-orange
Boiling point :600.2±55.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥9mg/mL
form :powder
pka :16.77±0.30(Predicted)
color :yellow-orange
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
Glycogen synthase kinase 3β (GSK3β) is a constitutively active serine/threonine protein kinase implicated in several important regulatory processes. It can phosphorylate β-catenin, an intracellular signal transducer in the Wnt signaling pathway, which leads to β-catenin degradation. IM-12 is a non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC50 = 53 nM). It has been shown to reduce proliferation and increase differentiation of a ReNCell VM cell line derived from human ventral midbrain. IM-12 is also reported to have a depolymerizing effect on in vitro tubulin assembly.More related product prices
252917-06-9 GSK-3BETA INHIBITOR XII WH-4-023 PD 0325901 405554-55-4 Y27632 (hydrochloride)Related product price
- 252917-06-9
$28-4070 - GSK-3BETA INHIBITOR XII
$37-2395.3 - WH-4-023
$39-1125
Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Hubei Jusheng Technology Co.,Ltd.
Chongqing Chemdad Co., Ltd
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
InvivoChem
