HIRUDIN
- $56.4 - $2030
- Product name: HIRUDIN
- CAS: 8001-27-2
- MF: C287H440N80O113S7
- MW: 7043.4877
- EINECS:232-279-1
- MDL Number:MFCD00081692
- Synonyms:hirudex ;recombinanthirudin ;HIRUDIN RECOMBINANT;DESULFATO-HIRUDIN;DESULFO-HIRUDIN;NATIVE HIRUDIN;[TYR63]HIRUDIN (HV1), LEECH;(63-tyrosine)hirudin (hv1),leech,rec. F. yeast
9 prices
Selected condition:
Brand
- American Custom Chemicals Corporation
- Sigma-Aldrich
Package
- 2G
- 10G
- 1ea
- 10units
- 100units
- 500units
- 2000units
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberPEP0011558
- Product descriptionRECOMBINANT HIRUDIN 95.00%
- Packaging2G
- Price$615.14
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberPEP0011558
- Product descriptionRECOMBINANT HIRUDIN 95.00%
- Packaging10G
- Price$747.77
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberH7016
- Product descriptionHirudin from leeches lyophilized powder, ≥1,500?ATU/mg protein (ATU = antithrombin units)
- Packaging10units
- Price$56.4
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberH7016
- Product descriptionHirudin from leeches lyophilized powder, ≥1,500?ATU/mg protein (ATU = antithrombin units)
- Packaging100units
- Price$463
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberH0393
- Product descriptionHirudin recombinant,expressedinunspecifiedhost,≥7,000?ATU/mgprotein(ATU=antithr
- Packaging100units
- Price$583
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number94581
- Product descriptionHirudin recombinant from yeast
- Packaging1ea
- Price$1360
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberH7016
- Product descriptionHirudin from leeches lyophilized powder, ≥1,500?ATU/mg protein (ATU = antithrombin units)
- Packaging500units
- Price$1880
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberH7016
- Product descriptionHirudin from leeches lyophilized powder, ≥1,500?ATU/mg protein (ATU = antithrombin units)
- Packaging2000units
- Price$1940
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberH0393
- Product descriptionHirudin recombinant,expressedinunspecifiedhost,≥7,000?ATU/mgprotein(ATU=antithr
- Packaging500units
- Price$2030
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
American Custom Chemicals Corporation | PEP0011558 | RECOMBINANT HIRUDIN 95.00% | 2G | $615.14 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | PEP0011558 | RECOMBINANT HIRUDIN 95.00% | 10G | $747.77 | 2021-12-16 | Buy |
Sigma-Aldrich | H7016 | Hirudin from leeches lyophilized powder, ≥1,500?ATU/mg protein (ATU = antithrombin units) | 10units | $56.4 | 2024-03-01 | Buy |
Sigma-Aldrich | H7016 | Hirudin from leeches lyophilized powder, ≥1,500?ATU/mg protein (ATU = antithrombin units) | 100units | $463 | 2024-03-01 | Buy |
Sigma-Aldrich | H0393 | Hirudin recombinant,expressedinunspecifiedhost,≥7,000?ATU/mgprotein(ATU=antithr | 100units | $583 | 2024-03-01 | Buy |
Sigma-Aldrich | 94581 | Hirudin recombinant from yeast | 1ea | $1360 | 2024-03-01 | Buy |
Sigma-Aldrich | H7016 | Hirudin from leeches lyophilized powder, ≥1,500?ATU/mg protein (ATU = antithrombin units) | 500units | $1880 | 2024-03-01 | Buy |
Sigma-Aldrich | H7016 | Hirudin from leeches lyophilized powder, ≥1,500?ATU/mg protein (ATU = antithrombin units) | 2000units | $1940 | 2024-03-01 | Buy |
Sigma-Aldrich | H0393 | Hirudin recombinant,expressedinunspecifiedhost,≥7,000?ATU/mgprotein(ATU=antithr | 500units | $2030 | 2024-03-01 | Buy |
Properties
storage temp. :2-8°C
form :lyophilized powder
color :white
Merck :13,4737
form :lyophilized powder
color :white
Merck :13,4737
Safety Information
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Description
Refludan was launched in Germany for heparin-associated thrombocytopenia. Originally isolated from the saliva of leeches (Hirudo medicinalis), the gene for recombinant hirudin was synthesized and expressed in Saccharomyces cerevisiae. The isolated protein is 65 amino acids differing from the native protein by the first two amino acids (Leu1 and Thr2) and Tyr63 is not sulfated, while it does retain the three disulfide bonds. Refludan is a potent, specific and almost irreversible inhibitor of thrombin with which it forms a 1:1 complex. The N-terminal domain binds to the active catalytic site of thrombin, while the C-terminal end binds to the anion binding exosite (fibrinogen binding cleft). It has several advantages over heparin: it can inhibit thrombin bound to extracellular matrices, does not require antithrombin Ⅲ as a cofactor, is not inhibited by activated platelet nor increases platelet activity, and is a pure, single compound with a single mechanism of action. It is useful for myocardial infarcts, unstable angia and cardiovascular events. Heparin treatment can be inhibited by platelets activated by the Fc fragment of antibodies developed to the antigen of heparin-platelet factor 4. A corresponding inactivation of Refuldan is not known.Related product price
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