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ChemicalBook >> CAS DataBase List >> Gilenia

Gilenia

Gilenia price.
  • $7 - $790
  • Product name: Gilenia
  • CAS: 162359-55-9
  • MF: C19H33NO2
  • MW: 307.47
  • EINECS:1308068-626-2
  • MDL Number:MFCD14705150
  • Synonyms:2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;Fingolimod(FTY720);Gilenia;Fingolimod;2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propandiol;FingoliMod Base;fenogliMod;1,3-Propanediol,2-aMino-2-[2-(4-octylphenyl)ethyl]-
28 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • 5g
  • 10g
  • ManufacturerAK Scientific
  • Product number7822CA
  • Product descriptionFingolimod
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484670
  • Product description2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+%
  • Packaging5mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484670
  • Product description2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+%
  • Packaging10mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484670
  • Product description2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+%
  • Packaging100mg
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484670
  • Product description2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+%
  • Packaging250mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484670
  • Product description2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+%
  • Packaging1g
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484670
  • Product description2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+%
  • Packaging5g
  • Price$385
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006834
  • Product descriptionFINGOLIMOD-D4 95.00%
  • Packaging5MG
  • Price$495.61
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2475B
  • Product descriptionFingolimod
  • Packaging10mg
  • Price$29
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2475B
  • Product descriptionFingolimod
  • Packaging100mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2475B
  • Product descriptionFingolimod
  • Packaging1g
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2475B
  • Product descriptionFingolimod
  • Packaging10g
  • Price$790
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBF164460
  • Product descriptionFingolimod
  • Packaging100mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBF164460
  • Product descriptionFingolimod
  • Packaging10mg
  • Price$86
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBF164460
  • Product descriptionFingolimod
  • Packaging250mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBF164460
  • Product descriptionFingolimod
  • Packaging500mg
  • Price$150
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 7822CA Fingolimod 10mg $108 2021-12-16 Buy
Ambeed A484670 2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+% 5mg $7 2021-12-16 Buy
Ambeed A484670 2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+% 10mg $10 2021-12-16 Buy
Ambeed A484670 2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+% 100mg $36 2021-12-16 Buy
Ambeed A484670 2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+% 250mg $53 2021-12-16 Buy
Ambeed A484670 2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+% 1g $133 2021-12-16 Buy
Ambeed A484670 2-Amino-2-(4-octylphenethyl)propane-1,3-diol 98+% 5g $385 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006834 FINGOLIMOD-D4 95.00% 5MG $495.61 2021-12-16 Buy
AvaChem 2475B Fingolimod 10mg $29 2021-12-16 Buy
AvaChem 2475B Fingolimod 100mg $45 2021-12-16 Buy
AvaChem 2475B Fingolimod 1g $119 2021-12-16 Buy
AvaChem 2475B Fingolimod 10g $790 2021-12-16 Buy
Biosynth Carbosynth BF164460 Fingolimod 100mg $55 2021-12-16 Buy
Biosynth Carbosynth BF164460 Fingolimod 10mg $86 2021-12-16 Buy
Biosynth Carbosynth BF164460 Fingolimod 250mg $100 2021-12-16 Buy
Biosynth Carbosynth BF164460 Fingolimod 500mg $150 2021-12-16 Buy

Properties

Melting point :103-105°
Boiling point :479.5±45.0 °C(Predicted)
Density :1.016
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Chloroform (Very Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly,
pka :12.20±0.20(Predicted)
form :Solid
color :Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H402 Harmful to aquatic life Hazardous to the aquatic environment, acute hazard Category 3
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Sphingosine 1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through four of the S1P receptors (S1P1, S1P3, S1P4, and S1P5). S1P1 plays a key role in the immune system, regulating lymphocyte egress from lymphoid tissues into the circulation. S1P receptors have been shown to influence cell proliferation, morphology, and migration and are also expressed on a wide range of cells that are involved in many biological processes relevant to multiple sclerosis (MS). Fingolimod (FTY720 (free base) of ) is a derivative of the fungal metabolite myriocin, a structural analog of sphingosine. In vivo, fingolimod is phosphorylated to form fingolimod-phosphate, which resembles naturally occurring S1P. Fingolimod-phosphate functions as an agonist at S1P1, S1P4, and S1P5 receptors (EC50 values of ~0.3-0.6 nM in vitro) and at 10-fold higher concentrations at S1P3 receptors (EC50 values of ~3 nM) but has no activity at S1P2 receptors. Fingolimod is a first-in-class orally bioavailable compound that has shown efficacy in advanced clinical trials for the treatment of MS through receptor-mediated actions both on the immune system and in the central nervous system. At 0.1-0.3 mg/kg it was shown to be highly effective at inhibiting the development of experimental autoimmune encephalomyelitis, an animal model of human MS, whereas concentrations 10-100-fold higher or in combination with classic immunosuppressants were required to prolong organ graft survival in animals.