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ChemicalBook >> CAS DataBase List >> Gemcitabine

Gemcitabine

Gemcitabine price.
  • $6 - $6080
  • Product name: Gemcitabine
  • CAS: 95058-81-4
  • MF: C9H11F2N3O4
  • MW: 263.2
  • EINECS:619-100-6
  • MDL Number:MFCD00869720
  • Synonyms:2'-Deoxy-2',2'-difluoro-D-cytidine;2''-DEOXY-2'',2''-DIFLUOROCYTIDINE(GEMCITABINE);2',2'-Difluorodeoxycytidine;Cytidine, 2'-deoxy-2',2'-difluoro-;NSC 613327;gencitabine base;2'-Deoxy-2',2'-difluro cytidine Hydrochloride;GEMCITABINE (2''-DEOXY-2'', 2''-DIFLUOROCYTIDINE)
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  • ManufacturerAHH
  • Product numberAPI-1280
  • Product descriptionGemcitabine 98%
  • Packaging25g
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ93775
  • Product descriptionGemcitabine
  • Packaging100g
  • Price$840
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA433642
  • Product descriptionGemcitabine 98+%
  • Packaging100mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA433642
  • Product descriptionGemcitabine 98+%
  • Packaging250mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA433642
  • Product descriptionGemcitabine 98+%
  • Packaging1g
  • Price$22
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA433642
  • Product descriptionGemcitabine 98+%
  • Packaging5g
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA433642
  • Product descriptionGemcitabine 98+%
  • Packaging10g
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA433642
  • Product descriptionGemcitabine 98+%
  • Packaging25g
  • Price$298
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA433642
  • Product descriptionGemcitabine 98+%
  • Packaging100g
  • Price$917
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002813
  • Product descriptionGEMCITABINE 95.00%
  • Packaging1G
  • Price$970.43
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002813
  • Product descriptionGEMCITABINE 95.00%
  • Packaging500MG
  • Price$795.8
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002813
  • Product descriptionGEMCITABINE 95.00%
  • Packaging100MG
  • Price$686.65
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8437
  • Product descriptionGemcitabine
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS004226
  • Product descriptionGemcitabine ≥98%
  • Packaging100mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS004226
  • Product descriptionGemcitabine ≥98%
  • Packaging250mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS004226
  • Product descriptionGemcitabine ≥98%
  • Packaging1g
  • Price$22
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1280 Gemcitabine 98% 25g $400 2021-12-16 Buy
AK Scientific J93775 Gemcitabine 100g $840 2021-12-16 Buy
Ambeed A433642 Gemcitabine 98+% 100mg $6 2021-12-16 Buy
Ambeed A433642 Gemcitabine 98+% 250mg $10 2021-12-16 Buy
Ambeed A433642 Gemcitabine 98+% 1g $22 2021-12-16 Buy
Ambeed A433642 Gemcitabine 98+% 5g $85 2021-12-16 Buy
Ambeed A433642 Gemcitabine 98+% 10g $147 2021-12-16 Buy
Ambeed A433642 Gemcitabine 98+% 25g $298 2021-12-16 Buy
Ambeed A433642 Gemcitabine 98+% 100g $917 2021-12-16 Buy
American Custom Chemicals Corporation API0002813 GEMCITABINE 95.00% 1G $970.43 2021-12-16 Buy
American Custom Chemicals Corporation API0002813 GEMCITABINE 95.00% 500MG $795.8 2021-12-16 Buy
American Custom Chemicals Corporation API0002813 GEMCITABINE 95.00% 100MG $686.65 2021-12-16 Buy
ApexBio Technology A8437 Gemcitabine 100mg $50 2021-12-16 Buy
Arctom AS004226 Gemcitabine ≥98% 100mg $6 2021-12-16 Buy
Arctom AS004226 Gemcitabine ≥98% 250mg $10 2021-12-16 Buy
Arctom AS004226 Gemcitabine ≥98% 1g $22 2021-12-16 Buy

Properties

Melting point :168,64 C
alpha :365 +425.36°; D +71.51°
Boiling point :482.7±55.0 °C(Predicted)
Density :1.84±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Methanol (Slightly), Water (Slightly, Heated)
pka :11.65±0.70(Predicted)
form :Solid
color :White to Off-White
CAS DataBase Reference :95058-81-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Gemcitabine (2’,2’-difluorodeoxycytidine; dFdCyd) is a novel deoxycytidine analogue with both structural and metabolic similarities to cytarabine. It has a broad spectrum of antitumor activity in preclinical murine leukemia and solid tumor models. This drug requires intracellular phosphorylation that results in the accumulation of difluorodeoxycytidine triphosphate (dFdCTP). The dFdCTP competes with deoxycytidine triphosphate (dCTP) for incorporation into DNA, which in turn inhibits DNA synthesis and terminates DNA chain elongation. In addition, this drug reduces intracellular deoxynucleoside triphosphate pools, presumably through the inhibition of ribonucleotide reductase.
Gemcitabine is used alone or with other treatments/medications to treat certain types of cancer (including breast cancer, non-small cell lung cancer, ovarian cancer, pancreatic cancer, bladder cancer, bone cancer, Ewing’s sarcoma, mesenchymal chondrosarcoma osteosarcoma, dedifferentiated chondrosarcoma, head and neck cancers-cancer of the nasopharynx, hepatobiliary cancers including gallbladder cancer, Hodgkin lymphoma, kidney cancer, malignant pleural mesothelioma, non Hodgkin lymphoma, non-melanoma skin cancer – dermatofibrosarcoma protuberans (DFSP), occult primary, small cell lung cancer, soft tissue sarcoma, testicular cancer, thymic malignancies, uterine malignancies). It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells. One commercial product of gemcitabine is Gemzar, which is supplied in a sterile form for intravenous use only.

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