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ChemicalBook >> CAS DataBase List >> GW441756

GW441756

GW441756 price.
  • $25 - $2395.3
  • Product name: GW441756
  • CAS: 504433-23-2
  • MF: C17H13N3O
  • MW: 275.3
  • EINECS:
  • MDL Number:MFCD08703104
  • Synonyms:1,3-DIHYDRO-3-[(1-METHYL-1H-INDOL-3-YL)METHYLENE]-2H-PYRROLO[3,2-B]PYRIDIN-2-ONE;GW 441756;Gw;2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-;(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-1H-PYRROLO[3,2-B]PYRIDIN-2-ONE;HYDROCHLORIDE
25 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
Package
  • 10
  • 1mg
  • 5mg
  • 10mg
  • 50
  • 10mM(in 1mL DMSO)
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • 1000mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1044-M001
  • Product descriptionGW-441756 ≥95%
  • Packaging1mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1044-M050
  • Product descriptionGW-441756 ≥95%
  • Packaging50mg
  • Price$491
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1044
  • Product descriptionGW441756
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2452AH
  • Product descriptionGW441756
  • Packaging25mg
  • Price$184
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2452AH
  • Product descriptionGW441756
  • Packaging100mg
  • Price$363
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1044
  • Product descriptionGW441756
  • Packaging50mg
  • Price$475
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000638
  • Product descriptionGW-441756 95.00%
  • Packaging5MG
  • Price$719.95
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2297
  • Product descriptionGW441756
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2297
  • Product descriptionGW441756
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2297
  • Product descriptionGW441756
  • Packaging50mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180863
  • Product descriptionGW441756 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180863
  • Product descriptionGW441756 >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180863
  • Product descriptionGW441756 >98%
  • Packaging1000mg
  • Price$2395.3
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16915
  • Product descriptionGW 441756 ≥95%
  • Packaging1mg
  • Price$25
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16915
  • Product descriptionGW 441756 ≥95%
  • Packaging5mg
  • Price$63
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16915
  • Product descriptionGW 441756 ≥95%
  • Packaging10mg
  • Price$113
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1044-M001 GW-441756 ≥95% 1mg $65 2021-12-16 Buy
Adipogen Life Sciences SYN-1044-M050 GW-441756 ≥95% 50mg $491 2021-12-16 Buy
AK Scientific SYN1044 GW441756 5mg $120 2021-12-16 Buy
AK Scientific 2452AH GW441756 25mg $184 2021-12-16 Buy
AK Scientific 2452AH GW441756 100mg $363 2021-12-16 Buy
AK Scientific SYN1044 GW441756 50mg $475 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000638 GW-441756 95.00% 5MG $719.95 2021-12-16 Buy
ApexBio Technology B2297 GW441756 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology B2297 GW441756 10mg $80 2021-12-16 Buy
ApexBio Technology B2297 GW441756 50mg $240 2021-12-16 Buy
Biorbyt Ltd orb180863 GW441756 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb180863 GW441756 >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb180863 GW441756 >98% 1000mg $2395.3 2021-12-16 Buy
Cayman Chemical 16915 GW 441756 ≥95% 1mg $25 2024-03-01 Buy
Cayman Chemical 16915 GW 441756 ≥95% 5mg $63 2024-03-01 Buy
Cayman Chemical 16915 GW 441756 ≥95% 10mg $113 2024-03-01 Buy

Properties

Boiling point :568.0±50.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :Soluble in DMSO (up to 5 mg/ml).
pka :11.04±0.20(Predicted)
form :solid
color :Orange
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The high affinity nerve growth factor (NGF) receptor, also known as NGF tyrosine kinase receptor A (TrkA), is involved in the development and maturation of the nervous system. Aberrant expression is associated with certain forms of cancer and congenital insensitivity to pain with anhidrosis. GW 441756 is a potent inhibitor of TrkA (IC50 = 2 nM). It displays >100-fold selectivity over a panel of related kinases. GW 441756 has been used to clarify the role of TrkA in regulating gene expression in neuroblastoma cells and, more recently, in amyloid-β protein precursor cleavage in neuroglioma cells.

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