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ChemicalBook >> CAS DataBase List >> GNE-9605

GNE-9605

GNE-9605 price.
  • $40 - $1800
  • Product name: GNE-9605
  • CAS: 1536200-31-3
  • MF: C17H20ClF4N7O
  • MW: 449.83
  • EINECS:
  • MDL Number:MFCD28167997
  • Synonyms:GNE-9605;N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine;Diazepam-d8 (exempt preparation);CS-1831;GNE-9605;GNE9605;GNE 9605;2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-;GNE-9605 USP/EP/BP
19 prices
Selected condition：
Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • CSNpharm
  • DC Chemicals
Package
  • 1mg
  • 10mg
  • 25mg
  • 100mg
  • 10mM(in 1mL DMSO)
  • 5MG
  • 50mg
  • 250mg
  • 1g
  • ManufacturerAmbeed
  • Product numberA369305
  • Product descriptionGNE-9605 98+%
  • Packaging100mg
  • Price$428
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA369305
  • Product descriptionGNE-9605 98+%
  • Packaging250mg
  • Price$642
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA369305
  • Product descriptionGNE-9605 98+%
  • Packaging1g
  • Price$1605
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004681
  • Product descriptionN2-(5-CHLORO-1-(3-FLUORO-1-(OXETAN-3-YL)PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL)-N4-METHYL-5-(TRIFLUOROMETHYL)PYRIMIDINE-2,4-DIAMINE 95.00%
  • Packaging5MG
  • Price$497.98
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4761
  • Product descriptionGNE-9605
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4761
  • Product descriptionGNE-9605
  • Packaging10mM(in 1mL DMSO)
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4761
  • Product descriptionGNE-9605
  • Packaging25mg
  • Price$348
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number23446
  • Product descriptionGNE-9605 ≥98%
  • Packaging1mg
  • Price$40
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23446
  • Product descriptionGNE-9605 ≥98%
  • Packaging5mg
  • Price$177
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23446
  • Product descriptionGNE-9605 ≥98%
  • Packaging10mg
  • Price$312
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23446
  • Product descriptionGNE-9605 ≥98%
  • Packaging25mg
  • Price$583
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM167742
  • Product descriptionN2-(5-chloro-1-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine 98%
  • Packaging100mg
  • Price$949
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003276
  • Product descriptionGNE-9605 98+%
  • Packaging10mg
  • Price$283
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003276
  • Product descriptionGNE-9605 98+%
  • Packaging25mg
  • Price$537
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003276
  • Product descriptionGNE-9605 98+%
  • Packaging50mg
  • Price$965
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN17916
  • Product descriptionGNE-9605
  • Packaging5mg
  • Price$102
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A369305 GNE-9605 98+% 100mg $428 2021-12-16 Buy
Ambeed A369305 GNE-9605 98+% 250mg $642 2021-12-16 Buy
Ambeed A369305 GNE-9605 98+% 1g $1605 2021-12-16 Buy
American Custom Chemicals Corporation INB0004681 N2-(5-CHLORO-1-(3-FLUORO-1-(OXETAN-3-YL)PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL)-N4-METHYL-5-(TRIFLUOROMETHYL)PYRIMIDINE-2,4-DIAMINE 95.00% 5MG $497.98 2021-12-16 Buy
ApexBio Technology B4761 GNE-9605 5mg $110 2021-12-16 Buy
ApexBio Technology B4761 GNE-9605 10mM(in 1mL DMSO) $160 2021-12-16 Buy
ApexBio Technology B4761 GNE-9605 25mg $348 2021-12-16 Buy
Cayman Chemical 23446 GNE-9605 ≥98% 1mg $40 2024-03-01 Buy
Cayman Chemical 23446 GNE-9605 ≥98% 5mg $177 2024-03-01 Buy
Cayman Chemical 23446 GNE-9605 ≥98% 10mg $312 2024-03-01 Buy
Cayman Chemical 23446 GNE-9605 ≥98% 25mg $583 2024-03-01 Buy
Chemenu CM167742 N2-(5-chloro-1-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine 98% 100mg $949 2021-12-16 Buy
Crysdot CD31003276 GNE-9605 98+% 10mg $283 2021-12-16 Buy
Crysdot CD31003276 GNE-9605 98+% 25mg $537 2021-12-16 Buy
Crysdot CD31003276 GNE-9605 98+% 50mg $965 2021-12-16 Buy
CSNpharm CSN17916 GNE-9605 5mg $102 2021-12-16 Buy

Properties

Boiling point :587.9±60.0 °C(Predicted)
Density :1.67±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥22.5 mg/mL in DMSO
form :solid
pka :5.04±0.60(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease.

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