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ChemicalBook >> CAS DataBase List >> DESMETHYL SILDENAFIL

DESMETHYL SILDENAFIL

DESMETHYL SILDENAFIL price.
  • $36 - $1593.9
  • Product name: DESMETHYL SILDENAFIL
  • CAS: 139755-82-1
  • MF: C21H28N6O4S
  • MW: 460.55
  • EINECS:
  • MDL Number:MFCD00908398
  • Synonyms:DESMETHYL SILDENAFIL;5-[2-Ethoxy-5-(1-piperazinylsulfonyl)phenyl]-1,6-dihydro-1-methyl-3-propyl- 7H-pyrazolo[4,3-d]pyrimidin-7-one;UK 103320;Sildenafil N-DesMethyl IMpurity;5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one;Sildenafil N-desmethyl;Sildenafil N-desmethy impurity;Sildenafil EP Impurity F (Sildenafil N-Desmethyl Metabolite)
29 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chemtos
  • Crysdot
  • Medical Isotopes, Inc.
  • TRC
Package
  • 1mg
  • 2mg
  • 5MG
  • 10mg
  • 25mg
  • 50MG
  • 100mg
  • 250mg
  • 1g
  • 5g
  • 10g
  • ManufacturerAK Scientific
  • Product numberJ11755
  • Product descriptionSildenafilEPImpurityF(N-DesmethylSildenafil)
  • Packaging25mg
  • Price$94
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY0500
  • Product descriptionN-Desmethylsildenafil
  • Packaging5g
  • Price$721
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ11755
  • Product descriptionSildenafilEPImpurityF(N-DesmethylSildenafil)
  • Packaging1g
  • Price$894
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ55575
  • Product descriptionN-Desmethylsildenafil
  • Packaging10g
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156415
  • Product description5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95%
  • Packaging250mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156415
  • Product description5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95%
  • Packaging1g
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156415
  • Product description5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95%
  • Packaging5g
  • Price$324
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0046132
  • Product descriptionSILDENAFIL PIPERAZINE IMPURITY 95.00%
  • Packaging5MG
  • Price$457.51
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberMTB0000257
  • Product descriptionN-DESMETHYL SILDENAFIL 95.00%
  • Packaging5MG
  • Price$738.1
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberMTB0000257
  • Product descriptionN-DESMETHYL SILDENAFIL 95.00%
  • Packaging50MG
  • Price$1593.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD21324
  • Product descriptionN-Desmethyl sildenafil
  • Packaging2mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD21324
  • Product descriptionN-Desmethyl sildenafil
  • Packaging5mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD21324
  • Product descriptionN-Desmethyl sildenafil
  • Packaging10mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD21324
  • Product descriptionN-Desmethyl sildenafil
  • Packaging25mg
  • Price$600
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD21324
  • Product descriptionN-Desmethyl sildenafil
  • Packaging50mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18208
  • Product descriptionN-Desmethyl Sildenafil ≥98%
  • Packaging1mg
  • Price$36
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J11755 SildenafilEPImpurityF(N-DesmethylSildenafil) 25mg $94 2021-12-16 Buy
AK Scientific Y0500 N-Desmethylsildenafil 5g $721 2021-12-16 Buy
AK Scientific J11755 SildenafilEPImpurityF(N-DesmethylSildenafil) 1g $894 2021-12-16 Buy
AK Scientific J55575 N-Desmethylsildenafil 10g $900 2021-12-16 Buy
Ambeed A156415 5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95% 250mg $44 2021-12-16 Buy
Ambeed A156415 5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95% 1g $115 2021-12-16 Buy
Ambeed A156415 5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95% 5g $324 2021-12-16 Buy
American Custom Chemicals Corporation API0046132 SILDENAFIL PIPERAZINE IMPURITY 95.00% 5MG $457.51 2021-12-16 Buy
American Custom Chemicals Corporation MTB0000257 N-DESMETHYL SILDENAFIL 95.00% 5MG $738.1 2021-12-16 Buy
American Custom Chemicals Corporation MTB0000257 N-DESMETHYL SILDENAFIL 95.00% 50MG $1593.9 2021-12-16 Buy
Biosynth Carbosynth FD21324 N-Desmethyl sildenafil 2mg $104 2021-12-16 Buy
Biosynth Carbosynth FD21324 N-Desmethyl sildenafil 5mg $200 2021-12-16 Buy
Biosynth Carbosynth FD21324 N-Desmethyl sildenafil 10mg $320 2021-12-16 Buy
Biosynth Carbosynth FD21324 N-Desmethyl sildenafil 25mg $600 2021-12-16 Buy
Biosynth Carbosynth FD21324 N-Desmethyl sildenafil 50mg $750 2021-12-16 Buy
Cayman Chemical 18208 N-Desmethyl Sildenafil ≥98% 1mg $36 2024-03-01 Buy

Properties

Melting point :158-160°C
Density :1.44±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml
form :A crystalline solid
pka :10.05±0.20(Predicted)
color :White to off-white
Stability :Moisture Sensitive

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Sildenafil is a potent cGMP-specific phosphodiesterase (PDE) inhibitor that is highly selective for PDE5 (IC50 = 3.6 nM). Inhibition of PDE5 prolongs nitric oxide-mediated relaxation of smooth muscle in a range of vascular tissues. N-Desmethyl sildenafil is a major metabolite of sildenafil. The conversion of sildenafil to this metabolite is affected by age and by renal and hepatic impairment.

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