Colesevelam

$95
Product name: Colesevelam
CAS: 182815-44-7
MF: C31H66Cl2N4O
MW: 581.8
EINECS:806-925-3
MDL Number:
Synonyms:Colesevelam and Colesevelam Hydrochloride;colesevelam hcl API;Colesevelam ;2-Propen-1-amine polymer with (chloromethyl)oxirane, N-2-propenyl-1-decanamine and N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride hydrochloride;Colesevelam USP/EP/BP;Colesevelam USP;Colesevelam HydrochlorideQ: What is Colesevelam Hydrochloride Q: What is the CAS Number of Colesevelam Hydrochloride Q: What is the storage condition of Colesevelam Hydrochloride Q: What are the applications of Colesevelam Hydrochloride;Colesevelam hydrochloride

Price1 Properties Safety Information Description

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Brand

Package

50mg

ManufacturerTRC
Product numberC640095
Product descriptionColesevelamHydrochloride(TechnicalGrade)
Packaging50mg
Price$95
Updated2021-12-16
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Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
TRC	C640095	ColesevelamHydrochloride(TechnicalGrade)	50mg	$95	2021-12-16	Buy

Properties

storage temp. :Store at -20°C
form :Solid
color :White to light yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321	Specific treatment (see … on this label).
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P362	Take off contaminated clothing and wash before reuse.

Description

Colesevelam hydrochloride was launched as Welchol (formerly known as Cholestagel) in the US for the reduction of elevated levels of serum LDL cholesterol and accordingly, the decrease of the risk of vascular disease in patients with primary hypercholesterolemia. This orally administered cationic hydrogel is a non-absorbable, water-insoluble polymer of an hexanaminium chloride with N-(2-propenyl) decanamine, 2-propen-1-amine hydrochloride and chloromethyloxirane. It acts as a powerful bile acid sequestering agent, this binding and blockage of bile acids having the end result of compelling the removal of LDL cholesterol from the blood stream into the liver. In animals fed with a cholesterol-rich diet for several weeks, colesevelam demonstrated a good maintenance of low serum cholesterol levels, this activity being significantly greater when compared with cholestyramine. In several placebo-controlled studies, this agent decreased total cholesterol levels by 6 to 10% and LDL cholesterol levels by 9 to 20%. Combination therapy with the co-administration of a HMG-CoA reductase inhibitor (or statin) and colesevelam produced an additional reduction of 8-16% in LDL-cholesterol levels above that obtained with the statin alone. Due to its unique water-absorbing hydrogel formulation, this polymer is not absorbed at all from the GI tract, and thus, it is said to have a lower rate of side-effects (as the constipating effect) than the previously marketed bile acid sequestrants. Colesevelam hydrochloride may be used as a monotherapy or as a dual therapy with statins.

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