Bufalin
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- $44 - $2900
- Product name: Bufalin
- CAS: 465-21-4
- MF: C24H34O4
- MW: 386.53
- EINECS:
- MDL Number:MFCD30207876
- Synonyms:22-dienolide,3,14-dihydroxy-,(3-beta,5-beta)-bufa-2 ;Bufalin, >=98%;22-dienolide,3-beta,14-dihydroxy-5-beta-bufa-2 ;BUFA-20,22-DIENOLIDE, 3,14-DIHYDROXY-, (3B,5B)-;(3BETA,5BETA)-3,14-DIHYDROXYBUFA-20,22-DIENOLIDE;3-BETA-14-DIHYDROXY-5-BETA-BUFA-20,22-DIENOLIDE;3BETA,14-DIHYDROXY-5BETA,20[22]-BUFADIENOLIDE;5BETA,20[22]-BUFADIENOLIDE-3BETA,14-DIOL
43 prices
Selected condition：
Brand
- Adipogen Life Sciences
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- JR MediChem
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0533-M010
- Product descriptionBufalin ≥98%(HPLC)
- Packaging10mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA206803
- Product description5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+%
- Packaging1mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA206803
- Product description5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+%
- Packaging5mg
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA206803
- Product description5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+%
- Packaging10mg
- Price$148
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA206803
- Product description5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+%
- Packaging25mg
- Price$251
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA206803
- Product description5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+%
- Packaging50mg
- Price$373
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA206803
- Product description5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+%
- Packaging100mg
- Price$554
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberSHG0006923
- Product descriptionBufalin 95.00%
- Packaging5MG
- Price$786.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberSHG0006923
- Product descriptionBufalin 95.00%
- Packaging50MG
- Price$1963.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberN1507
- Product descriptionBufalin
- Packaging20mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS055116
- Product description5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one ≥98%
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS055116
- Product description5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one ≥98%
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN99947
- Product descriptionBufalin ≥98%
- Packaging20mg
- Price$148
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS055116
- Product description5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one ≥98%
- Packaging100mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number1054
- Product descriptionBufalin
- Packaging5mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number1054
- Product descriptionBufalin
- Packaging10mg
- Price$75
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0533-M010 | Bufalin ≥98%(HPLC) | 10mg | $60 | 2021-12-16 | Buy |
| Ambeed | A206803 | 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+% | 1mg | $44 | 2021-12-16 | Buy |
| Ambeed | A206803 | 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+% | 5mg | $99 | 2021-12-16 | Buy |
| Ambeed | A206803 | 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+% | 10mg | $148 | 2021-12-16 | Buy |
| Ambeed | A206803 | 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+% | 25mg | $251 | 2021-12-16 | Buy |
| Ambeed | A206803 | 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+% | 50mg | $373 | 2021-12-16 | Buy |
| Ambeed | A206803 | 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 98+% | 100mg | $554 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0006923 | Bufalin 95.00% | 5MG | $786.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0006923 | Bufalin 95.00% | 50MG | $1963.5 | 2021-12-16 | Buy |
| ApexBio Technology | N1507 | Bufalin | 20mg | $200 | 2021-12-16 | Buy |
| Arctom | AS055116 | 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one ≥98% | 5mg | $72 | 2021-12-16 | Buy |
| Arctom | AS055116 | 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one ≥98% | 10mg | $125 | 2021-12-16 | Buy |
| Arctom | CFN99947 | Bufalin ≥98% | 20mg | $148 | 2021-12-16 | Buy |
| Arctom | AS055116 | 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one ≥98% | 100mg | $540 | 2021-12-16 | Buy |
| AvaChem | 1054 | Bufalin | 5mg | $45 | 2021-12-16 | Buy |
| AvaChem | 1054 | Bufalin | 10mg | $75 | 2021-12-16 | Buy |
Properties
Melting point :242-243°
alpha :D -20°
Boiling point :556.6±50.0 °C(Predicted)
Density :1.226±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:36.0(Max Conc. mg/mL);93.14(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);64.68(Max Conc. mM)
Ethanol:27.5(Max Conc. mg/mL);71.15(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.78(Max Conc. mM) pka :15.01±0.70(Predicted)
form :White to off-white solid
color :White to off-white
InChIKey :QEEBRPGZBVVINN-ONGIWDLKSA-N
alpha :D -20°
Boiling point :556.6±50.0 °C(Predicted)
Density :1.226±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:36.0(Max Conc. mg/mL);93.14(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);64.68(Max Conc. mM)
Ethanol:27.5(Max Conc. mg/mL);71.15(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.78(Max Conc. mM) pka :15.01±0.70(Predicted)
form :White to off-white solid
color :White to off-white
InChIKey :QEEBRPGZBVVINN-ONGIWDLKSA-N
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Bufalin is a cardiotonic steroid first isolated from toad venom and used in traditional Asian medicine. It inhibits the Na+/K+-ATPase transporter (Kds = 42, 45, and 40 nM for the α1, α2, and α3 subunits, respectively). Intravenously administered bufalin is cleared rapidly, with a plasma half-life of 25 minutes in dogs and rats. Bufalin inhibits steroid receptor coactivator 1 (SRC-1) and SRC-3 at doses as low as 5 nM, promotes the degradation of SRC-3 protein, and inhibits cancer cell growth both in vitro and in vivo. It can also impact the action and expression of several other proteins and kinases as well as induce apoptosis in various cancer cells.Related product price
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