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ChemicalBook >> CAS DataBase List >> Almotriptan

Almotriptan

Almotriptan price.
  • $35 - $1550
  • Product name: Almotriptan
  • CAS: 154323-57-6
  • MF: C17H25N3O2S
  • MW: 335.46
  • EINECS:1312995-182-4
  • MDL Number:MFCD00927104
  • Synonyms:LAS-31416-d6;ALMOTRIPTAN(SUBJECTTOPATENETFREE);Almotriptan;N,N-Dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]-ethanamine;dimethyl-[2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethyl]amine;AlMotriptan API;N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-Indole-3-ethanamine;ALMOTRIPTAN-D6
17 prices
Selected condition:
Brand
  • American Custom Chemicals Corporation
  • AvaChem
  • Biorbyt Ltd
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Usbiological
Package
  • 5MG
  • Y0002140
  • 1mg
  • 10mg
  • 25mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006650
  • Product descriptionALMOTRIPTAN-D6 95.00%
  • Packaging5MG
  • Price$497.17
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3080B
  • Product descriptionAlmotriptan
  • Packaging5mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3080B
  • Product descriptionAlmotriptan
  • Packaging25mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3080B
  • Product descriptionAlmotriptan
  • Packaging100mg
  • Price$179
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3080B
  • Product descriptionAlmotriptan
  • Packaging1g
  • Price$690
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134783
  • Product descriptionAlmotriptan >99%
  • Packaging100mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134783
  • Product descriptionAlmotriptan >99%
  • Packaging250mg
  • Price$606.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134783
  • Product descriptionAlmotriptan >99%
  • Packaging1g
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDCAPI1478
  • Product descriptionAlmotriptan >99%
  • Packaging100mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDCAPI1478
  • Product descriptionAlmotriptan >99%
  • Packaging250mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDCAPI1478
  • Product descriptionAlmotriptan >99%
  • Packaging1g
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerMatrix Scientific
  • Product number091207
  • Product descriptionN,N-Dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)-methyl)-1H-indol-3-yl)ethanamine 95+%
  • Packaging250mg
  • Price$184
  • Updated2021-12-16
  • Buy
  • ManufacturerMatrix Scientific
  • Product number091207
  • Product descriptionN,N-Dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)-methyl)-1H-indol-3-yl)ethanamine 95+%
  • Packaging1g
  • Price$457
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product numberD33837
  • Product descriptionAlmotriptan-d3Benzoate
  • Packaging1mg
  • Price$640
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product numberD33837
  • Product descriptionAlmotriptan-d3Benzoate
  • Packaging5mg
  • Price$1550
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberY0002140
  • Product descriptionAlmotriptan for system suitability CRS, European Pharmacopoeia (EP) Reference Standard
  • PackagingY0002140
  • Price$156
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation RDL0006650 ALMOTRIPTAN-D6 95.00% 5MG $497.17 2021-12-16 Buy
AvaChem 3080B Almotriptan 5mg $35 2021-12-16 Buy
AvaChem 3080B Almotriptan 25mg $85 2021-12-16 Buy
AvaChem 3080B Almotriptan 100mg $179 2021-12-16 Buy
AvaChem 3080B Almotriptan 1g $690 2021-12-16 Buy
Biorbyt Ltd orb134783 Almotriptan >99% 100mg $510 2021-12-16 Buy
Biorbyt Ltd orb134783 Almotriptan >99% 250mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb134783 Almotriptan >99% 1g $1504.5 2021-12-16 Buy
DC Chemicals DCAPI1478 Almotriptan >99% 100mg $250 2021-12-16 Buy
DC Chemicals DCAPI1478 Almotriptan >99% 250mg $300 2021-12-16 Buy
DC Chemicals DCAPI1478 Almotriptan >99% 1g $1000 2021-12-16 Buy
Matrix Scientific 091207 N,N-Dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)-methyl)-1H-indol-3-yl)ethanamine 95+% 250mg $184 2021-12-16 Buy
Matrix Scientific 091207 N,N-Dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)-methyl)-1H-indol-3-yl)ethanamine 95+% 1g $457 2021-12-16 Buy
Medical Isotopes, Inc. D33837 Almotriptan-d3Benzoate 1mg $640 2021-12-16 Buy
Medical Isotopes, Inc. D33837 Almotriptan-d3Benzoate 5mg $1550 2021-12-16 Buy
Sigma-Aldrich Y0002140 Almotriptan for system suitability CRS, European Pharmacopoeia (EP) Reference Standard Y0002140 $156 2024-03-01 Buy

Properties

Boiling point :538.7±60.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
pka :16.92±0.30(Predicted)
form :Solid
color :White to off-white
CAS DataBase Reference :154323-57-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P233 Keep container tightly closed.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304 IF INHALED:
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P340 Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362 Take off contaminated clothing and wash before reuse.
P403 Store in a well-ventilated place.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Almotriptan was first marketed in Spain as a new medicine against acute attacks of migraine. It is the fifth agent belonging to the “triptan” class to be launched after sumatriptan, naratriptan, zolmitriptan and rizatriptan. This close structural analog of sumatriptan can be prepared in six steps from 4-nitrobenzylsulfonyl chloride with a Fischer indole synthesis as the key step. Almotriptan acts as a dual 5-HT1D/1B agonist with a 35 to 51-fold selectivity versus 5-HT1A and 5-HT7 receptors respectively as well as having insignificant affinity for the most relevant nonserotonergic receptors (K1>1μM). Its agonistic effect on 5-HT,n receptors of trigeminal sensory neurons turns off neurogenic inflammation by inhibiting the release of neuropeptides such as calcitonin gene-related peptide, neurokinin A and substance P. Concomitantly, its action on the 5-HT1B receptors in meningeal arteries relieves the vasodilatation of these vessels associated with migraine attacks. Almotriptan causes selective concentration-dependent vasoconstriction of human meningeal and temporal arteries (with EC50 of 0.03 and 0.7 μM) compared to basilar (EC50 = 3.5 μM) and pulmonary arteries (EC50>10μM) or rabbit mesenteric and renal arteries (EC50>100 μM). Although it is predominantly cleared by the kidneys as unchanged drug (45%) or transformed into inactive metabolites by monoamine oxidase A (MAO-A) and CYP3A4 enzymes in the liver, almotriptan has the highest oral bioavailability (70%) of the triptans and has a half-life of 3.5 h. The therapeutic dose of 12.5 mg is well tolerated, shows a rapid onset of action (30 min) and low recurrence rate compared to sumatriptan.

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