Actinomycin D
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- $25 - $2691.1
- Product name: Actinomycin D
- CAS: 50-76-0
- MF: C62H86N12O16
- MW: 1255.42
- EINECS:200-063-6
- MDL Number:MFCD00005033
- Synonyms:2-Amino-N,N'-bis[hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide;Actinomycin D, Actinomycin IV, Actinomycin C1, Dactinomycin;Dactinomycin, DTM;Actinomycin C1, Dactinomycin;Actactinomycin A IV;Cosmogen;actinomycin7 ;actinomycinaiv
55 prices
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Brand
- Adipogen Life Sciences
- Alfa Aesar
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Biorbyt Ltd
- Cayman Chemical
- Chem-Impex
- DC Chemicals
- Frontier Specialty Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 2mg
- 10MG
- 25mg
- 1mg
- 5mg
- 10
- 10mM(in 1mL DMSO)
- 50MG
- 100mg
- 250mg
- 1ml
- 1g
- 5x1ml
- 1set
- 48Tests
- 96Tests
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0089-M025
- Product descriptionActinomycin D ≥98%(HPLC)
- Packaging25mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ60148
- Product descriptionActinomycin D
- Packaging5mg
- Price$129
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ67160
- Product descriptionActinomycin D, 1 mg/ml in DMSO, sterile-filtered
- Packaging1ml
- Price$203
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ67160
- Product descriptionActinomycin D, 1 mg/ml in DMSO, sterile-filtered
- Packaging5x1ml
- Price$607
- Updated2024-03-01
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002202
- Product descriptionDACTINOMYCIN 95.00%
- Packaging5MG
- Price$665.98
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002202
- Product descriptionDACTINOMYCIN 95.00%
- Packaging10MG
- Price$679.37
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002202
- Product descriptionDACTINOMYCIN 95.00%
- Packaging50MG
- Price$984.98
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4448
- Product descriptionActinomycin D
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4448
- Product descriptionActinomycin D
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4448
- Product descriptionActinomycin D
- Packaging10mM(in 1mL DMSO)
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4448
- Product descriptionActinomycin D
- Packaging50mg
- Price$395
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIA0175
- Product descriptionActinomycin D >97%
- Packaging1mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIA0175
- Product descriptionActinomycin D >97%
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIA0175
- Product descriptionActinomycin D >97%
- Packaging25mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146196
- Product descriptionActinomycin D >99%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146196
- Product descriptionActinomycin D >99%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | BVT-0089-M025 | Actinomycin D ≥98%(HPLC) | 25mg | $120 | 2021-12-16 | Buy |
| Alfa Aesar | J60148 | Actinomycin D | 5mg | $129 | 2024-03-01 | Buy |
| Alfa Aesar | J67160 | Actinomycin D, 1 mg/ml in DMSO, sterile-filtered | 1ml | $203 | 2024-03-01 | Buy |
| Alfa Aesar | J67160 | Actinomycin D, 1 mg/ml in DMSO, sterile-filtered | 5x1ml | $607 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | API0002202 | DACTINOMYCIN 95.00% | 5MG | $665.98 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002202 | DACTINOMYCIN 95.00% | 10MG | $679.37 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002202 | DACTINOMYCIN 95.00% | 50MG | $984.98 | 2021-12-16 | Buy |
| ApexBio Technology | A4448 | Actinomycin D | 5mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A4448 | Actinomycin D | 10mg | $90 | 2021-12-16 | Buy |
| ApexBio Technology | A4448 | Actinomycin D | 10mM(in 1mL DMSO) | $250 | 2021-12-16 | Buy |
| ApexBio Technology | A4448 | Actinomycin D | 50mg | $395 | 2021-12-16 | Buy |
| Apolloscientific | BIA0175 | Actinomycin D >97% | 1mg | $50 | 2021-12-16 | Buy |
| Apolloscientific | BIA0175 | Actinomycin D >97% | 5mg | $110 | 2021-12-16 | Buy |
| Apolloscientific | BIA0175 | Actinomycin D >97% | 25mg | $195 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146196 | Actinomycin D >99% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146196 | Actinomycin D >99% | 250mg | $1356.6 | 2021-12-16 | Buy |
Properties
Melting point :251-253 °C
Boiling point :848°C (rough estimate)
Density :1.0757 (rough estimate)
refractive index :1.5700 (estimate)
Flash point :87℃
storage temp. :2-8°C
solubility :ethanol, DMSO: Stable in aqueous solutions at 2-8 °C.soluble
form :powder
pka :8.94±0.70(Predicted)
color :red, powder
optical activity :[α]/D alpha: 28/D (Rotation: -315 degrees (c=0.25% in methanol))
Water Solubility :SOLUBLE
Merck :13,2828
BRN :605235
Stability :Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible.
CAS DataBase Reference :50-76-0(CAS DataBase Reference)
IARC :3 (Vol. 10, Sup 7) 1987
EPA Substance Registry System :Actinomycin D (50-76-0)
Boiling point :848°C (rough estimate)
Density :1.0757 (rough estimate)
refractive index :1.5700 (estimate)
Flash point :87℃
storage temp. :2-8°C
solubility :ethanol, DMSO: Stable in aqueous solutions at 2-8 °C.soluble
form :powder
pka :8.94±0.70(Predicted)
color :red, powder
optical activity :[α]/D alpha: 28/D (Rotation: -315 degrees (c=0.25% in methanol))
Water Solubility :SOLUBLE
Merck :13,2828
BRN :605235
Stability :Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible.
CAS DataBase Reference :50-76-0(CAS DataBase Reference)
IARC :3 (Vol. 10, Sup 7) 1987
EPA Substance Registry System :Actinomycin D (50-76-0)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate. DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low concentrations (~10 nM), which interferes with RNA synthesis and ultimately leads to cell death. Actinomycin D is widely used as an anticancer agent for treating a variety of tumors and along with its fluorescent derivative, 7-aminoactinomycin D has become a useful tool in biochemistry and molecular biology research as a marker for DNA.Related product price
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