Aclidinium bromide
- $32 - $2200
- Product name: Aclidinium bromide
- CAS: 320345-99-1
- MF: C13H10BrN
- MW: 564.56
- EINECS:825-171-6
- MDL Number:MFCD22683690
- Synonyms:(3R)-(2-Hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide;1-Azoniabicyclo(2.2.2)octane, 3-((hydroxydi-2-thienylacetyl)oxy)-1-(3-phenoxypropyl)-, bromide, (3R)-;Unii-uqw7uf9N91;ACLIDINIUM BROMIDE INTERMEDIATES;ACLIDINIUM BROMIDE;LAS 34273;(3R)-3-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-1-(3-phenoxypropyl)quinuclidin-1-ium bromide;1-Azoniabicyclo[2.2.2]octane, 3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-, bromide (1:1), (3R)-
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Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
Package
- 5mg
- 10mg
- 25mg
- 10mM(in 1mL DMSO)
- 50mg
- 100mg
- 250mg
- 500mg
- 1G
- ManufacturerAK Scientific
- Product number2195AH
- Product descriptionAclidiniumbromide
- Packaging5mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2195AH
- Product descriptionAclidiniumbromide
- Packaging10mg
- Price$107
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008120
- Product descriptionACLIDINIUM BROMIDE 95.00%
- Packaging1G
- Price$1726.73
- Updated2021-12-16
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- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008120
- Product descriptionACLIDINIUM BROMIDE 95.00%
- Packaging10MG
- Price$315
- Updated2021-12-16
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- ManufacturerApexBio Technology
- Product numberB1609
- Product descriptionAclidiniumBromide
- Packaging5mg
- Price$60
- Updated2021-12-16
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- ManufacturerApexBio Technology
- Product numberB1609
- Product descriptionAclidiniumBromide
- Packaging10mM(in 1mL DMSO)
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1609
- Product descriptionAclidiniumBromide
- Packaging10mg
- Price$90
- Updated2021-12-16
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- ManufacturerApexBio Technology
- Product numberB1609
- Product descriptionAclidiniumBromide
- Packaging50mg
- Price$290
- Updated2021-12-16
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- ManufacturerApexBio Technology
- Product numberB1609
- Product descriptionAclidiniumBromide
- Packaging100mg
- Price$490
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA31012
- Product descriptionAclidinium bromide
- Packaging500mg
- Price$600
- Updated2021-12-16
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- ManufacturerBiosynth Carbosynth
- Product numberFA31012
- Product descriptionAclidinium bromide
- Packaging250mg
- Price$337.5
- Updated2021-12-16
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- ManufacturerBiosynth Carbosynth
- Product numberFA31012
- Product descriptionAclidinium bromide
- Packaging100mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA31012
- Product descriptionAclidinium bromide
- Packaging50mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA31012
- Product descriptionAclidinium bromide
- Packaging10mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number20699
- Product descriptionAclidinium (bromide) ≥95%
- Packaging5mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20699
- Product descriptionAclidinium (bromide) ≥95%
- Packaging10mg
- Price$61
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 2195AH | Aclidiniumbromide | 5mg | $96 | 2021-12-16 | Buy |
AK Scientific | 2195AH | Aclidiniumbromide | 10mg | $107 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0008120 | ACLIDINIUM BROMIDE 95.00% | 1G | $1726.73 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0008120 | ACLIDINIUM BROMIDE 95.00% | 10MG | $315 | 2021-12-16 | Buy |
ApexBio Technology | B1609 | AclidiniumBromide | 5mg | $60 | 2021-12-16 | Buy |
ApexBio Technology | B1609 | AclidiniumBromide | 10mM(in 1mL DMSO) | $70 | 2021-12-16 | Buy |
ApexBio Technology | B1609 | AclidiniumBromide | 10mg | $90 | 2021-12-16 | Buy |
ApexBio Technology | B1609 | AclidiniumBromide | 50mg | $290 | 2021-12-16 | Buy |
ApexBio Technology | B1609 | AclidiniumBromide | 100mg | $490 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA31012 | Aclidinium bromide | 500mg | $600 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA31012 | Aclidinium bromide | 250mg | $337.5 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA31012 | Aclidinium bromide | 100mg | $150 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA31012 | Aclidinium bromide | 50mg | $100 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA31012 | Aclidinium bromide | 10mg | $45 | 2021-12-16 | Buy |
Cayman Chemical | 20699 | Aclidinium (bromide) ≥95% | 5mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 20699 | Aclidinium (bromide) ≥95% | 10mg | $61 | 2024-03-01 | Buy |
Properties
Melting point :230 °C(Solv: acetonitrile (75-05-8))
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :DMSO (Slightly, Heated), Methanol (Slightly)
form :Solid
color :White to Pale Orange
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :DMSO (Slightly, Heated), Methanol (Slightly)
form :Solid
color :White to Pale Orange
Safety Information
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Description
In July 2012, aclidinium bromide was approved in the US and the EU for long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disorder (COPD). Aclidinium bromide is in the latter category, acting as a selective antagonist for the muscarinic M3 receptor. M3 receptors are localized in airway smooth muscle, and are the primary subtype responsible for bronchial and tracheal smooth muscle contraction. Muscarinic antagonists are well-established bronchodilators that are effective for treating COPD, but these agents have unwanted side effects if systemically absorbed. Systemic exposure can be limited by inhaled administration, which is the route of delivery for aclidinium bromide. In addition, aclidinium bromide was designed to undergo rapid hydrolysis in human plasma, providing inactive acid and alcohol products, and reducing the potential for systemic side effects. Aclidinium bromide was identified amongst a series of quaternary ammonium (3R)-quinuclidinol esters as having the best combination of high potency (M3 Ki=0.14 nM), long duration of action (29 h for 50% reduction of therapeutic effect in a guinea pig bronchoconstriction model), low oral absorption, and rapid plasma degradation. The synthesis of aclidinium bromide was achieved by reaction of dimethyl oxalate with 2-thienylmagnesium bromide followed by treatment of the resulting methyl ester with (3R)-quinuclidinol in the presence of sodium hydride. Quaternization of the amine was achieved by treatment with 3-phenoxypropyl bromide to give aclidinium bromide.More related product prices
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