AS703026
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- $25 - $2996
- Product name: AS703026
- CAS: 1236699-92-5
- MF: C15H15FIN3O3
- MW: 431.2
- EINECS:
- MDL Number:MFCD16660676
- Synonyms:AS703026;N-[(2S)-2,3-Dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide;(S)-N-(2,3-dihydroxypropyl)-3-(2-fluoro-4-iodophenylaMino)isonicotinaMide;4-PyridinecarboxaMide, N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)aMino]-;MSC1936369B;PiMasertib (AS-703026);AS703026/MSC1936369B;PiMasertib
35 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
- Usbiological
Package
- 5mg
- 25MG
- 10mM(in 1mL DMSO)
- 1MG
- 10mg
- 50mg
- 100mg
- 200mg
- 250MG
- 500mg
- 5g
- 10g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1190-M050
- Product descriptionAS-703026 ≥95%
- Packaging50mg
- Price$421
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7392
- Product descriptionPimasertib
- Packaging100mg
- Price$324
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000706
- Product descriptionAS-703026 95.00%
- Packaging250MG
- Price$1732.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000706
- Product descriptionAS-703026 95.00%
- Packaging25MG
- Price$721.88
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000706
- Product descriptionAS-703026 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5573
- Product descriptionPimasertib(AS-703026)
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5573
- Product descriptionPimasertib(AS-703026)
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5573
- Product descriptionPimasertib(AS-703026)
- Packaging10mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5573
- Product descriptionPimasertib(AS-703026)
- Packaging25mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5573
- Product descriptionPimasertib(AS-703026)
- Packaging100mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0186
- Product descriptionAS-703026
- Packaging1mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0186
- Product descriptionAS-703026
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0186
- Product descriptionAS-703026
- Packaging10mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60277
- Product descriptionPimasertib ≥98%
- Packaging10mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD32913
- Product descriptionPimasertib
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD32913
- Product descriptionPimasertib
- Packaging50mg
- Price$210
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1190-M050 | AS-703026 ≥95% | 50mg | $421 | 2021-12-16 | Buy |
| AK Scientific | X7392 | Pimasertib | 100mg | $324 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000706 | AS-703026 95.00% | 250MG | $1732.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000706 | AS-703026 95.00% | 25MG | $721.88 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000706 | AS-703026 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
| ApexBio Technology | A5573 | Pimasertib(AS-703026) | 5mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A5573 | Pimasertib(AS-703026) | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
| ApexBio Technology | A5573 | Pimasertib(AS-703026) | 10mg | $65 | 2021-12-16 | Buy |
| ApexBio Technology | A5573 | Pimasertib(AS-703026) | 25mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A5573 | Pimasertib(AS-703026) | 100mg | $280 | 2021-12-16 | Buy |
| Apolloscientific | BISN0186 | AS-703026 | 1mg | $58 | 2021-12-16 | Buy |
| Apolloscientific | BISN0186 | AS-703026 | 5mg | $95 | 2021-12-16 | Buy |
| Apolloscientific | BISN0186 | AS-703026 | 10mg | $124 | 2021-12-16 | Buy |
| Arctom | CFN60277 | Pimasertib ≥98% | 10mg | $168 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD32913 | Pimasertib | 10mg | $95 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD32913 | Pimasertib | 50mg | $210 | 2021-12-16 | Buy |
Properties
Boiling point :623.2±55.0 °C(Predicted)
Density :1.769
storage temp. :Store at -20°C
solubility :≥21.55 mg/mL in DMSO; insoluble in H2O; ≥10.36 mg/mL in EtOH with ultrasonic
form :solid
pka :12.82±0.46(Predicted)
color :Light yellow to khaki
Density :1.769
storage temp. :Store at -20°C
solubility :≥21.55 mg/mL in DMSO; insoluble in H2O; ≥10.36 mg/mL in EtOH with ultrasonic
form :solid
pka :12.82±0.46(Predicted)
color :Light yellow to khaki
Safety Information
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Description
The mitogen-activated protein kinases, MEK1 and 2, are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the Ras-Raf-MEK-ERK pathway and are often upregulated in a variety of cancer cell types. AS-703026 is an orally bioavailable small molecule that selectively binds to and inhibits MEK1/2, preventing the activation of downstream effector proteins and transcription factors. It potently inhibits growth and survival of human INA-6 multiple myeloma cells and cytokine-induced osteoclast differentiation with IC50 values of 10 and 18.2 nM, respectively. In mice bearing H929 MM xenograft tumors, 30 mg/kg AS-703026 reduced tumor growth significantly, which correlated with downregulated ERK1/2 activity, induced PARP cleavage, and decreased microvessels in vivo. At 10 μM, AS-703026 supressed proliferation and transformation of K-Ras mutated colorectal cancer cells resistant to EGFR antibody therapy.Related product price
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