4beta-Hydroxywithanolide E

$505.84 - $763
Product name: 4beta-Hydroxywithanolide E
CAS: 54334-04-2
MF: C28H38O8
MW: 502.6
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MDL Number:
Synonyms:4beta-Hydroxywithanolide E;4β-Hydroxywithanolide E;Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, δ-lactone, (4β,5β,6β,17α,22R)-;4β-HydroxywithanolideE;5β,6β-epoxy-4β,14,17α,20,22R-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, ?-lactone

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Brand

American Custom Chemicals Corporation
Cayman Chemical

Package

ManufacturerAmerican Custom Chemicals Corporation
Product numberINB0001928
Product description4BETA-HYDROXYWITHANOLIDE E 95.00%
Packaging5MG
Price$505.84
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number27245
Product description4β-Hydroxywithanolide E
Packaging1mg
Price$763
Updated2024-03-01
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	INB0001928	4BETA-HYDROXYWITHANOLIDE E 95.00%	5MG	$505.84	2021-12-16	Buy
Cayman Chemical	27245	4β-Hydroxywithanolide E	1mg	$763	2024-03-01	Buy

Properties

storage temp. :Store at -20°C
solubility :Chloroform: soluble; Ethanol: soluble; Methanol: soluble
form :A crystalline solid

Safety Information

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Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

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Description

4β-Hydroxywithanolide E is a withanolide steroidal lactone that has been found in P. peruviana and has anti-inflammatory and anticancer activities.^1,2,3 It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells and TNF-α-induced NF-κB activity in HEK293 cells (IC₅₀s = 0.32 and 0.04 μM, respectively).¹ 4β-Hydroxywithanolide E (5 μM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels and Akt and STAT1 phosphorylation in RAW 264.7 cells.² It inhibits Wnt signaling in HCT116 and SW480 colorectal cancer cells (IC₅₀s = 1.85 and 2.67 μM, respectively).³ 4β-Hydroxywithanolide E inhibits the proliferation of HCT116, SW480, HT-29, and LoVo cells (IC₅₀s = 0.24-0.51 μM). It halts the cell cycle at the G₀/G₁ phase in HCT116 and HT-29 cells and induces apoptosis in HCT116 and SW480 cells in a concentration-dependent manner. 4β-Hydroxywithanolide E (10 mg/kg per day for 14 days) reduces tumor growth in an HCT116 mouse xenograft model.

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