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ChemicalBook >> CAS DataBase List >> 15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA price.
  • $64 - $497
  • Product name: 15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA
  • CAS: 41639-71-8
  • MF: C23H32O5
  • MW: 388.5
  • EINECS:
  • MDL Number:MFCD05863952
  • Synonyms:9ALPHA-11ALPHA,15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID;15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA;15(R)-17-phenyl trinor Prostaglandin F2α;Bimatoprost Impurity 3;(15R)-Bimatoprost Acid/(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-5-heptenoic Acid;Bimatoprost Impurity 6;Bimatoprost Acid 15-Epimer;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-, (5Z)-
4 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • ManufacturerAK Scientific
  • Product number1209AH
  • Product description15(R)-17-PhenyltrinorprostaglandinF2alpha
  • Packaging5mg
  • Price$410
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16814
  • Product description15(R)-17-phenyl trinor Prostaglandin F2α ≥98%
  • Packaging1mg
  • Price$64
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16814
  • Product description15(R)-17-phenyl trinor Prostaglandin F2α ≥98%
  • Packaging5mg
  • Price$280
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16814
  • Product description15(R)-17-phenyl trinor Prostaglandin F2α ≥98%
  • Packaging10mg
  • Price$497
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1209AH 15(R)-17-PhenyltrinorprostaglandinF2alpha 5mg $410 2021-12-16 Buy
Cayman Chemical 16814 15(R)-17-phenyl trinor Prostaglandin F2α ≥98% 1mg $64 2024-03-01 Buy
Cayman Chemical 16814 15(R)-17-phenyl trinor Prostaglandin F2α ≥98% 5mg $280 2024-03-01 Buy
Cayman Chemical 16814 15(R)-17-phenyl trinor Prostaglandin F2α ≥98% 10mg $497 2024-03-01 Buy

Properties

Boiling point :597.4±50.0 °C(Predicted)
Density :1.219±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 1 mg/ml
form :Oil
pka :4.76±0.10(Predicted)
color :Colourless

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or “unnatural” isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.