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ChemicalBook >> CAS DataBase List >> Pemetrexed Disodium Heptahydrate

Pemetrexed Disodium Heptahydrate

Pemetrexed Disodium Heptahydrate price.
  • $23 - $1732.5
  • Product name: Pemetrexed Disodium Heptahydrate
  • CAS: 357166-29-1
  • MF: C20H24N5NaO7
  • MW: 469.43
  • EINECS:639-569-0
  • MDL Number:MFCD09029394
  • Synonyms:N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate;Pemetrexed disodium hepthydrate;PeMetrexed disodiuM 7-hydrate;L-GlutaMic acid, N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-, disodiuM salt, heptahydrate;Pemetrexed for system suitability;Pemetrexed (sodium salt hydrate);N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hepthydrate;7-dihydro-4-oxo-3H-pyrrolo[2
19 prices
Selected condition:
Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 5MG
  • 10MG
  • 50mg
  • 100MG
  • y0001538
  • 250mg
  • 500mg
  • y0001539
  • 1g
  • 5g
  • 25g
  • ManufacturerAmbeed
  • Product numberA209789
  • Product descriptionSodium(S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioateheptahydrate 98+%
  • Packaging1g
  • Price$23
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA209789
  • Product descriptionSodium(S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioateheptahydrate 98+%
  • Packaging5g
  • Price$93
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA209789
  • Product descriptionSodium(S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioateheptahydrate 98+%
  • Packaging25g
  • Price$372
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024628
  • Product descriptionPEMETREXED DISODIUM HEPTAHYDRATE 95.00%
  • Packaging5MG
  • Price$171.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024628
  • Product descriptionPEMETREXED DISODIUM HEPTAHYDRATE 95.00%
  • Packaging10MG
  • Price$721.88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024628
  • Product descriptionPEMETREXED DISODIUM HEPTAHYDRATE 95.00%
  • Packaging100MG
  • Price$1732.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14269
  • Product descriptionPemetrexed (sodium salt hydrate) ≥98%
  • Packaging5mg
  • Price$61
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14269
  • Product descriptionPemetrexed (sodium salt hydrate) ≥98%
  • Packaging10mg
  • Price$112
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14269
  • Product descriptionPemetrexed (sodium salt hydrate) ≥98%
  • Packaging50mg
  • Price$468
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14269
  • Product descriptionPemetrexed (sodium salt hydrate) ≥98%
  • Packaging100mg
  • Price$816
  • Updated2024-03-01
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number66649
  • Product descriptionPemetrexed disodium heptahydrate
  • Packaging250mg
  • Price$1475
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number66649
  • Product descriptionPemetrexed disodium heptahydrate
  • Packaging10mg
  • Price$610
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPHR1596
  • Product descriptionPemetrexed for system suitability
  • Packaging500mg
  • Price$105
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1490
  • Product descriptionPemetrexed for system suitability ≥98% (HPLC)
  • Packaging10mg
  • Price$108
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberY0001539
  • Product descriptionPemetrexed disodium heptahydrate European Pharmacopoeia (EP) Reference Standard
  • Packagingy0001539
  • Price$153
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberY0001538
  • Product descriptionPemetrexed for system suitability European Pharmacopoeia (EP) Reference Standard
  • Packagingy0001538
  • Price$153
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A209789 Sodium(S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioateheptahydrate 98+% 1g $23 2021-12-16 Buy
Ambeed A209789 Sodium(S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioateheptahydrate 98+% 5g $93 2021-12-16 Buy
Ambeed A209789 Sodium(S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioateheptahydrate 98+% 25g $372 2021-12-16 Buy
American Custom Chemicals Corporation API0024628 PEMETREXED DISODIUM HEPTAHYDRATE 95.00% 5MG $171.6 2021-12-16 Buy
American Custom Chemicals Corporation API0024628 PEMETREXED DISODIUM HEPTAHYDRATE 95.00% 10MG $721.88 2021-12-16 Buy
American Custom Chemicals Corporation API0024628 PEMETREXED DISODIUM HEPTAHYDRATE 95.00% 100MG $1732.5 2021-12-16 Buy
Cayman Chemical 14269 Pemetrexed (sodium salt hydrate) ≥98% 5mg $61 2024-03-01 Buy
Cayman Chemical 14269 Pemetrexed (sodium salt hydrate) ≥98% 10mg $112 2024-03-01 Buy
Cayman Chemical 14269 Pemetrexed (sodium salt hydrate) ≥98% 50mg $468 2024-03-01 Buy
Cayman Chemical 14269 Pemetrexed (sodium salt hydrate) ≥98% 100mg $816 2024-03-01 Buy
Medical Isotopes, Inc. 66649 Pemetrexed disodium heptahydrate 250mg $1475 2021-12-16 Buy
Medical Isotopes, Inc. 66649 Pemetrexed disodium heptahydrate 10mg $610 2021-12-16 Buy
Sigma-Aldrich PHR1596 Pemetrexed for system suitability 500mg $105 2024-03-01 Buy
Sigma-Aldrich SML1490 Pemetrexed for system suitability ≥98% (HPLC) 10mg $108 2024-03-01 Buy
Sigma-Aldrich Y0001539 Pemetrexed disodium heptahydrate European Pharmacopoeia (EP) Reference Standard y0001539 $153 2024-03-01 Buy
Sigma-Aldrich Y0001538 Pemetrexed for system suitability European Pharmacopoeia (EP) Reference Standard y0001538 $153 2024-03-01 Buy

Properties

storage temp. :2-8°C
solubility :H2O: soluble30mg/mL, clear
form :powder
color :white to beige
Stability :Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month.
InChIKey :AEZRDYKQLPDYEH-YTCXBBKHNA-N
SMILES :C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH].O |&1:20,r|

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Pemetrexed is pyrrotopyrimidine-based, multi-targeted antifolate with broad in vivo antitumor activity. Originally identified as a highly efficient substrate for folylpolyglutamate synthase, pemetrexed potently inhibits multiple folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM). Its antiproliferative activity has been demonstrated in a wide variety of solid tumors, including non-small cell lung, breast, mesothelioma, colorectal, pancreatic, gastric, bladder, cervix, and head and neck.