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ChemicalBook >> CAS DataBase List >> 7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde

7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde

7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde price.
  • $7 - $676
  • Product name: 7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde
  • CAS: 14003-96-4
  • MF: C11H8O4
  • MW: 204.18
  • EINECS:
  • MDL Number:MFCD12027255
  • Synonyms:2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-4-methyl-2-oxo-;8C;4u8C;4Μ8C;7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde;4-Methyl-7-hydroxy-8-formylcoumarin;7-Hydroxy-8-formyl-4-methylcoumarin;8-Formyl-7-hydroxy-4-methyl-2H-1-benzopyran-2-one
31 prices
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  • Ambeed
  • American Custom Chemicals Corporation
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 2x10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAmbeed
  • Product numberA460722
  • Product description7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98%
  • Packaging5mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA460722
  • Product description7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98%
  • Packaging10mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA460722
  • Product description7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98%
  • Packaging25mg
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA460722
  • Product description7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98%
  • Packaging50mg
  • Price$24
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA460722
  • Product description7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98%
  • Packaging100mg
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA460722
  • Product description7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98%
  • Packaging250mg
  • Price$69
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA460722
  • Product description7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98%
  • Packaging1g
  • Price$159
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001414
  • Product description4-M-8-C 98.00%
  • Packaging5MG
  • Price$505.54
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1902
  • Product description4μ8C 99%
  • Packaging2x10mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22110
  • Product description4μ8C ≥98%
  • Packaging5mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22110
  • Product description4μ8C ≥98%
  • Packaging10mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22110
  • Product description4μ8C ≥98%
  • Packaging25mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22110
  • Product description4μ8C ≥98%
  • Packaging50mg
  • Price$178
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6409
  • Product description4μ8C 99.72%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6409
  • Product description4μ8C 99.72%
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6409
  • Product description4μ8C 99.72%
  • Packaging25mg
  • Price$120
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A460722 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98% 5mg $7 2021-12-16 Buy
Ambeed A460722 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98% 10mg $10 2021-12-16 Buy
Ambeed A460722 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98% 25mg $16 2021-12-16 Buy
Ambeed A460722 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98% 50mg $24 2021-12-16 Buy
Ambeed A460722 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98% 100mg $36 2021-12-16 Buy
Ambeed A460722 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98% 250mg $69 2021-12-16 Buy
Ambeed A460722 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 98% 1g $159 2021-12-16 Buy
American Custom Chemicals Corporation INB0001414 4-M-8-C 98.00% 5MG $505.54 2021-12-16 Buy
Axon Medchem Axon1902 4μ8C 99% 2x10mg $176 2021-12-16 Buy
Cayman Chemical 22110 4μ8C ≥98% 5mg $37 2024-03-01 Buy
Cayman Chemical 22110 4μ8C ≥98% 10mg $68 2024-03-01 Buy
Cayman Chemical 22110 4μ8C ≥98% 25mg $116 2024-03-01 Buy
Cayman Chemical 22110 4μ8C ≥98% 50mg $178 2024-03-01 Buy
ChemScene CS-6409 4μ8C 99.72% 5mg $50 2021-12-16 Buy
ChemScene CS-6409 4μ8C 99.72% 10mg $70 2021-12-16 Buy
ChemScene CS-6409 4μ8C 99.72% 25mg $120 2021-12-16 Buy

Properties

Melting point :189-190℃ (ethanol )
Boiling point :398.3±42.0 °C(Predicted)
Density :1.541
refractive index :1.641
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :6.22±0.20(Predicted)
form :Yellow powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :RTHHSXOVIJWFQP-UHFFFAOYSA-N
CAS DataBase Reference :14003-96-4

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P285 In case of inadequate ventilation wear respiratory protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Description

4μ8C (14003-96-4) is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50?= 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity.1?Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells.2?Blocks production of IL-4, IL-5 and IL-13 production in T cells.3?4μ8C prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells.4

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