1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide
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- $28 - $3136.5
- Product name: 1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide
- CAS: 1396772-26-1
- MF: C32H37N5O3
- MW: 539.67
- EINECS:-0
- MDL Number:MFCD25372029
- Synonyms:EPZ005687;EPZ-005687;1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)ph;1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide;EPZ005687;1H-Indazole-4-carboxamide, 1-cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-;1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide EPZ 005687;EPZ 005687 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide;EPZ 00568
23 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1unit
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 1000mg
- ManufacturerAK Scientific
- Product numberSYN3050
- Product descriptionEPZ005687
- Packaging100mg
- Price$570
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4171
- Product descriptionEPZ005687
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4171
- Product descriptionEPZ005687
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4171
- Product descriptionEPZ005687
- Packaging25mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180981
- Product descriptionEPZ005687 >98%
- Packaging100mg
- Price$986
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180981
- Product descriptionEPZ005687 >98%
- Packaging250mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180981
- Product descriptionEPZ005687 >98%
- Packaging1000mg
- Price$3136.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13966
- Product descriptionEPZ005687 ≥98%
- Packaging5mg
- Price$86
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13966
- Product descriptionEPZ005687 ≥98%
- Packaging10mg
- Price$152
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13966
- Product descriptionEPZ005687 ≥98%
- Packaging25mg
- Price$336
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13966
- Product descriptionEPZ005687 ≥98%
- Packaging50mg
- Price$588
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM150834
- Product description1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide 98%
- Packaging100mg
- Price$858
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1215
- Product descriptionEPZ005687 99.49%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1215
- Product descriptionEPZ005687 99.49%
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1215
- Product descriptionEPZ005687 99.49%
- Packaging50mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1215
- Product descriptionEPZ005687 99.49%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN3050 | EPZ005687 | 100mg | $570 | 2021-12-16 | Buy |
| ApexBio Technology | A4171 | EPZ005687 | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A4171 | EPZ005687 | 5mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A4171 | EPZ005687 | 25mg | $200 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180981 | EPZ005687 >98% | 100mg | $986 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180981 | EPZ005687 >98% | 250mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180981 | EPZ005687 >98% | 1000mg | $3136.5 | 2021-12-16 | Buy |
| Cayman Chemical | 13966 | EPZ005687 ≥98% | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 13966 | EPZ005687 ≥98% | 10mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 13966 | EPZ005687 ≥98% | 25mg | $336 | 2024-03-01 | Buy |
| Cayman Chemical | 13966 | EPZ005687 ≥98% | 50mg | $588 | 2024-03-01 | Buy |
| Chemenu | CM150834 | 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide 98% | 100mg | $858 | 2021-12-16 | Buy |
| ChemScene | CS-1215 | EPZ005687 99.49% | 5mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-1215 | EPZ005687 99.49% | 10mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-1215 | EPZ005687 99.49% | 50mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-1215 | EPZ005687 99.49% | 100mg | $450 | 2021-12-16 | Buy |
Properties
Boiling point :797.9±60.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥3.86 mg/mL in DMSO
form :solid
pka :11.88±0.10(Predicted)
color :Off-white to yellow
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥3.86 mg/mL in DMSO
form :solid
pka :11.88±0.10(Predicted)
color :Off-white to yellow
Safety Information
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Description
EPZ005687 is a potent, selective inhibitor of the lysine methyltranferase EZH2 (Ki = 24 nM), the enzymatic subunit of polycomb repressive complex 2 (PRC2). It acts competitively with the EZH2 substrate S-adenosylmethionine. EPZ005687 has greater than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against EZH1. It blocks trimethylation of the PRC2 target histone 3 lysine 27 (IC50 = 80 nM), decreasing the proliferation of lymphoma cells carrying mutant, but not wild-type, EZH2.More related product prices
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