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ChemicalBook >> CAS DataBase List >> 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]

5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]

5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a] price.
  • $37 - $2395.3
  • Product name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]
  • CAS: 1062368-49-3
  • MF: C22H16N4O
  • MW: 352.39
  • EINECS:
  • MDL Number:MFCD28099805
  • Synonyms:(ML347);5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a];ML-347(LDN-193719);5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;LDN 193719;Quinoline, 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-;5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline ML-347(LDN-193719);LDN 193719 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
36 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 1mg
  • 5mg
  • 10mg
  • 50
  • 50mg
  • 250mg
  • 10mM(in 1mL DMSO)
  • 100mg
  • 1000mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5450
  • Product descriptionML347
  • Packaging100mg
  • Price$931
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5450
  • Product descriptionML347
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY1884
  • Product descriptionML347
  • Packaging5mg
  • Price$143
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA616413
  • Product description5-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
  • Packaging1mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA616413
  • Product description5-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
  • Packaging5mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA616413
  • Product description5-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
  • Packaging10mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3688
  • Product descriptionML347
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3688
  • Product descriptionML347
  • Packaging10mM(in 1mL DMSO)
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3688
  • Product descriptionML347
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3688
  • Product descriptionML347
  • Packaging50mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181404
  • Product descriptionML347 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181404
  • Product descriptionML347 >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181404
  • Product descriptionML347 >98%
  • Packaging1000mg
  • Price$2395.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFM137700
  • Product descriptionML 347
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFM137700
  • Product descriptionML 347
  • Packaging50mg
  • Price$332.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17640
  • Product descriptionML-347 ≥95%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5450 ML347 100mg $931 2021-12-16 Buy
AK Scientific SYN5450 ML347 10mg $160 2021-12-16 Buy
AK Scientific Y1884 ML347 5mg $143 2021-12-16 Buy
Ambeed A616413 5-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% 1mg $50 2021-12-16 Buy
Ambeed A616413 5-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% 5mg $112 2021-12-16 Buy
Ambeed A616413 5-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% 10mg $168 2021-12-16 Buy
ApexBio Technology B3688 ML347 5mg $60 2021-12-16 Buy
ApexBio Technology B3688 ML347 10mM(in 1mL DMSO) $70 2021-12-16 Buy
ApexBio Technology B3688 ML347 10mg $90 2021-12-16 Buy
ApexBio Technology B3688 ML347 50mg $350 2021-12-16 Buy
Biorbyt Ltd orb181404 ML347 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb181404 ML347 >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb181404 ML347 >98% 1000mg $2395.3 2021-12-16 Buy
Biosynth Carbosynth FM137700 ML 347 10mg $95 2021-12-16 Buy
Biosynth Carbosynth FM137700 ML 347 50mg $332.5 2021-12-16 Buy
Cayman Chemical 17640 ML-347 ≥95% 1mg $37 2024-03-01 Buy

Properties

Melting point :209-210℃
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥5.87 mg/mL in DMSO with gentle warming
form :solid
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Description

Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. ML-347 is a 5-quinoline compound that inhibits ALK1 and ALK2 with IC50 values of 46 and 32 nM, respectively. It demonstrates >300-fold selectivity for ALK2 over ALK3, ALK6, and VEGF type 2 receptor (IC50s = 10.8, 9.8, and 19.7 μM, respectively) and is inactive at ALK4, ALK5, BMP type 2 receptors, TGF-β type 2 receptor, and AMPK. In a functional assay, ML-347 was shown to inhibit BMP4 signaling with an IC50 value of 152 nM.

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