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Mauck George J. Atiee Jennifer McCulloh Laurie Reynolds Nadene Zack David R. Friend DOI: 10.1093/jac/dkac386; Journal of Antimicrobial Chemotherapy, 78, 1, 2022-11-24.; Abstract: Objectives: To evaluate pharmacokinetics (PK) of a single dose of an investigational 2% clindamycin phosphate vaginal gel in healthy women by assessment of plasma and vaginal clindamycin concentrations over 7 days, and assess safety. Methods: Single-centre, Phase 1, single-dose PK study. Blood and vaginal samples were collected daily and safety was evaluated through to Day 7. Results: Twenty-one subjects were enrolled; 20 completed the study. Plasma clindamycin concentrations demonstrated quantifiable values in all subjects through to 24 h post-dose, remaining above the limits of quantification (LOQ) through to 48 h for the majority of subjects. Systemic exposure (AUC0–t) was 1179 (range 62–3822) h·ng/mL. Arithmetic mean AUC0–24 was 818 (range 51–3287) h·ng/mL. Vaginal clindamycin phosphate levels were relatively high 24 h following administration in 15/21 subjects (6 subjects had values > © The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. Journal Journal of Antimicrobial Chemotherapy © The Author(s) 2022. 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