Nitrobenzene
Product identifier
- Product name: Nitrobenzene
- CBnumber: CB7854756
- CAS: 98-95-3
- EINECS Number: 202-716-0
- Synonyms: nitrobenzene,Nitrobenzol
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: Nitrobenzene
- Synonyms: nitrobenzene,Nitrobenzol
- CAS: 98-95-3
- EC number: 202-716-0
- MF: C6H5NO2
- MW: 123.11
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Nitrogen oxides (NOx) Combustible.
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
Use water spray to cool unopened containers.
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet- brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Avoid exposure - obtain special instructions before use. Advice on safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.
Advice on protection against fire and explosion
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.
Hygiene measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Store under nitrogen.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentFace shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: butyl-rubber
Minimum layer thickness: 0,3 mm Break through time: 480 min
Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)
Splash contact
Material: Nature latex/chloroprene Minimum layer thickness: 0,6 mm Break through time: 40 min
Material tested:Lapren? (KCL 706 / Aldrich Z677558, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Information on basic physicochemical properties
- Appearancecolorless, yellow liquid, clear
- Odourpungent
- Odour ThresholdNo data available d) pH 8,0 - 8,5 at 1,00000 g/l at 20,0 °C Melting point/freezing point Initial boiling point and boiling range Melting point/range: 5 - 6 °C - lit. 210 - 211 °C - lit. Flash point 88,0 °C - closed cup Evaporation rate No data available Flammability (solid, gas) Upper/lower flammability or explosive limits No data available Upper explosion limit: 40 %(V) Lower explosion limit: 1,8 %(V) Vapour pressure 66,7 hPa at 120,0 °C 0,3 hPa at 20,0 °C Vapour density No data available Density 1,196 g/cm3 at 25 °C - lit. Relative density No data available Water solubility 1,9 g/l at 20 °C Partition coefficient: n-octanol/water Autoignition temperature log Pow: 1,86 at 24,5 °C 482,0 °C Decomposition temperature No data available Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available Explosive properties No data available Oxidizing properties No data available
- Melting point/freezing pointMelting point/range: 5 - 6 °C - lit.
- Initial boiling point and boiling range 210 - 211 °C - lit.
- Flash point88,0 °C - closed cup
- Evaporation rate190 °F
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limits Upper explosion limit: 40 %(V) Lower explosion limit: 1,8 %(V)
- Vapour pressure 66,7 hPa at 120,0 °C 0,3 hPa at 20,0 °C
- Vapour density 0.15 mm Hg ( 20 °C)
- Relative density4.2 (vs air)
- Water solubility1,9 g/l at 20 °C
- Partition coefficient: n-octanol/waterlog Pow: 1,86 at 24,5 °C
- Autoignition temperature 482,0 °C
- Decomposition temperatureNo data available
- ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
- Henry's Law Constant9.86 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
Other safety information
Surface tension 43,4 mN/m at 20,0 °C
Reactivity
No data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
Heat, flames and sparks.
Incompatible materials
Strong oxidizing agents, Strong reducing agents, Strong bases
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicityRemarks: Behavioral:Altered sleep time (including change in righting reflex). Lungs, Thorax, or Respiration:Dyspnea.
(RTECS)
Oral
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Lacrimation. Behavioral:Tremor.
(RTECS)
LD50 Dermal - Rabbit - 760 mg/kg Remarks: (ECHA)
Result: No skin irritation - 24 h Remarks: (ECHA)
Result: No eye irritation
Remarks: (ECHA)
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation Result: negative
Remarks: (ECHA)
Test Type: Micronucleus test Species: Mouse
Cell type: Bone marrow
Application Route: Intraperitoneal injection Method: OECD Test Guideline 474
Result: negative
Test Type: unscheduled DNA synthesis assay Species: Rat
Cell type: Liver cells Application Route: Oral
Method: OECD Test Guideline 486 Result: negative
Toxicity
static test EC50 - Daphnia magna (Water flea) - 35 mg/l - 48 h
Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 50 - 60 % - Readily biodegradable. (OECD Test Guideline 301F)
Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 42 d
at 25 °C - 0,125 mg/l(Nitrobenzene)
Bioconcentration factor (BCF): 3,1 - 4,8 (OECD Test Guideline 305C)
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Harmful to aquatic life with long lasting effects.
Waste treatment methods
Product
This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.
IncompatibilitiesConcentrated nitric acid, nitrogen tetroxide; caustics; phosphorus pentachloride; chemically-active metals, such as tin or zinc. Violent reaction with strong oxidizers and reducing agents. Attacks many plastics. Forms thermally unstable compounds with many organic and inorganic compounds.
Waste DisposalIncineration (982℃, 2.0 seconds minimum) with scrubbing for nitrogen oxides abatement . Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Contaminated packaging
Dispose of as unused product.
UN number
ADR/RID: 1662 IMDG: 1662 IATA: 1662
UN proper shipping name
Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.