1,2-Dimethoxyethane
Product identifier
- Product name: 1,2-Dimethoxyethane
- CBnumber: CB9232185
- CAS: 110-71-4
- EINECS Number: 203-794-9
- Synonyms: DME,1,2-dimethoxyethane
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: 1,2-Dimethoxyethane
- Synonyms: DME,1,2-dimethoxyethane
- CAS: 110-71-4
- EC number: 203-794-9
- MF: C4H10O2
- MW: 90.12
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors. Risk of dust explosion.
Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.
Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Further information
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
| HEALTH | 1 | Exposure would cause irritation with only minor residual injury (e.g. acetone, sodium bromate, potassium chloride) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.
Environmental precautions
Do not let product enter drains. Risk of explosion.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb?). Dispose of properly. Clean up affected area.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.
Test for peroxide formation periodically and before distillation.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentUse equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Full contact Material: Viton?
Minimum layer thickness: 0,7 mm Break through time: 480 min
Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Splash contact Material: Nitrile rubber
Minimum layer thickness: 0,4 mm Break through time: 10 min
Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M)
Flame retardant antistatic protective clothing.
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type: Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Do not let product enter drains. Risk of explosion.
Information on basic physicochemical properties
- Appearancecolorless liquid, clear
- Odourether-like
- Odour Thresholdnot determined
- pHca.7neutral
- Melting point/freezing pointMelting point/range: -58 °C - lit.
- Initial boiling point and boiling range85 °C - lit.
- Flash point5 °C - closed cup
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limits Upper explosion limit: 10,4 %(V) Lower explosion limit: 1,6 %(V)
- Vapour pressure 87 hPa at 25 °C - OECD Test Guideline 104
- Vapour density 3,11 - (Air = 1.0)
- Relative density0,867 g/cm3 at 25 °C - lit. 0,87 at 20 °C - OECD Test Guideline 109
- Water solubility1.000 g/l at 25 °C - soluble
- Partition coefficient: n-octanol/waterlog Pow: -0,21 at 25 °C - (experimental) - Bioaccumulation is not expected.
- Autoignition temperatureNo data available
- Decomposition temperatureNo data available
- ViscosityViscosity, kinematic: 0,48 mm2/s at 20 °C - OECD Test Guideline 114 Viscosity, dynamic: 0,42 mPa.s at 20 °C - OECD Test Guideline 114
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
- λmaxλ: 220 nm Amax: 1.00
λ: 250 nm Amax: 0.20
λ: 300 nm Amax: 0.03
λ: 350-400 nm Amax: 0.01
Other safety information
Surface tension 70,7 mN/m at 1g/l at 23 °C
- OECD Test Guideline 115
Relative vapor density
3,11 - (Air = 1.0)
Reactivity
Formation of peroxides possible.
Vapors may form explosive mixture with air.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) . Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
Warming. Moisture.
Incompatible materials
Oxidizing agents, Strong acids, Strong oxidizing agents
Hazardous decomposition products
Peroxides
In the event of fire: see section 5
Information on toxicological effects
Acute toxicityAcute toxicity estimate Inhalation - 11,1 mg/l (Expert judgment)
Remarks: (Regulation (EC) No 1272/2008, Annex VI) Acute toxicity estimate Inhalation - 11,1 mg/l (Expert judgment)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
LD50 Dermal - Rat - female - > 5.000 mg/kg (OECD Test Guideline 402)
Result: Irritating to skin. - 24 h (OECD Test Guideline 404)
Result: No eye irritation - 24 h (OECD Test Guideline 405)
Result: negative
(OECD Test Guideline 429)
Remarks: The value is given in analogy to the following substances: 1-ethoxy-2-(2- methoxyethoxy)ethane
Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 482
Result: negative
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Test Type: sister chromatid exchange assay Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 479
Result: positive
Test Type: In vivo micronucleus test Species: Mouse
Cell type: Bone marrow Application Route: Oral
Method: OECD Test Guideline 474 Result: negative
Test Type: Chromosome aberration test Species: Chinese hamster
Cell type: Bone marrow Application Route: Oral
Method: OECD Test Guideline 475 Result: negative
Toxicity
Remarks: The value is given in analogy to the following substances: Tegdme
semi-static test EC50 - Daphnia magna (Water flea) - 4.000 mg/l - 48 h
(OECD Test Guideline 202)
9.120 mg/l - 72 h
(OECD Test Guideline 201)
Persistence and degradability
Biodegradability aerobic - Exposure time 48 d
Result: 16 % - According to the results of tests of biodegradability this product is not readily biodegradable.
(OECD Test Guideline 302B)
Chemical Oxygen Demand (COD)
1.700 mg/g
Remarks: (External MSDS)
Bioaccumulative potential
Due to the distribution coefficient n-octanol/water, accumulation in organisms is not expected.
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
UN number
ADR/RID: 2252 IMDG: 2252 IATA: 2252
UN proper shipping name
| | ADR/RID: 1,2-DIMETHOXYETHANE IMDG: 1,2-DIMETHOXYETHANE | |
| IATA: 1,2-Dimethoxyethane | ||
| 14.3 | Transport hazard class(es) ADR/RID: 3 IMDG: 3 | IATA: 3 |
| 14.4 | Packaging group ADR/RID: II IMDG: II | IATA: II |
| 14.5 | Environmental hazards ADR/RID: no IMDG Marine pollutant: no | IATA: no |
| 14.6 | Special precautions for user No data available | |
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.