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Chemical Safety Data Sheet MSDS / SDS

5'-O-Dimethoxytrityl-deoxythymidine

Revision Date:2024-12-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: 5'-O-Dimethoxytrityl-deoxythymidine
  • CBnumber: CB9780929
  • CAS: 40615-39-2
  • EINECS Number: 255-003-1
  • Synonyms: DMT-dT,DMT-thymidine

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
Precautionary statements
P405 Store locked up.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
Hazard statements
H335 May cause respiratory irritation
H319 Causes serious eye irritation
H315 Causes skin irritation

SECTION 3: Composition/information on ingredients

Substance

  • Product name: 5'-O-Dimethoxytrityl-deoxythymidine
  • Synonyms: DMT-dT,DMT-thymidine
  • CAS: 40615-39-2
  • EC number: 255-003-1
  • MF: C31H32N2O7
  • MW: 544.59

SECTION 4: First aid measures

Description of first aid measures

General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx) Combustible.

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

No data available

NFPA 704

0
1
0
HEALTH 0 Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials
FIRE 1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on protection against fire and explosion

Provide appropriate exhaust ventilation at places where dust is formed.

Hygiene measures

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Store in cool place.

Storage stability

Recommended storage temperature 2 - 8 °C

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment
Eye/face protection

Use equipment for eye protection tested and approved under appropriate

government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Body Protection

Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Appearancelight brown crystalline
  • OdourNo data available
  • Odour ThresholdNo data available
  • pHNo data available
  • Melting point/freezing pointMelting point: 142,7 °C at ca.1.013,25 hPa - OECD Test Guideline 102
  • Initial boiling point and boiling range ca.240 °C at 1.013,3 hPa - OECD Test Guideline 103 - Decomposition
  • Flash pointNo data available
  • Evaporation rateNo data available
  • Flammability (solid, gas)The product is not flammable. - Test N.1: Test method for readily combustible solids
  • Upper/lower flammability or explosive limitsNo data available
  • Vapour pressure< 0,1 hPa at 25 °C - OECD Test Guideline 104
  • Vapour density No data available
  • Relative densityca.1,27 at 20 °C - OECD Test Guideline 109
  • Water solubilityca.3 g/l at 20 °C - OECD Test Guideline 105
  • Partition coefficient: n-octanol/waterlog Pow: 4,61 at 20 °C - (calculated) - Potential bioaccumulation
  • Autoignition temperatureNo data available
  • Decomposition temperature ca.240 °C -
  • ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available

Other safety information

No data available

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

No data available

Incompatible materials

Strong oxidizing agents

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
LD50 Oral - Rat - female - > 2.000 mg/kg (OECD Test Guideline 423)
Skin corrosion/irritation
Skin - reconstructed human epidermis (RhE)
Result: No irritation (OECD Test Guideline 439)
Serious eye damage/eye irritation
Eyes - In vitro study Result: No eye irritation (OECD Test Guideline 492)
Respiratory or skin sensitization
(OECD Test Guideline 429)
Germ cell mutagenicity
Ames test
Salmonella typhimurium Result: negative
Carcinogenicity
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available

SECTION 12: Ecological information

Toxicity

No data available

Toxicity to daphnia and other aquatic invertebrates

static test NOEC - Daphnia magna (Water flea) - >= 100 mg/l - 48 h (OECD Test Guideline 202)

Toxicity to algae
static test EC10 - Pseudokirchneriella subcapitata - 2,98 mg/l - 72 h (OECD Test Guideline 201)

static test ErC50 - Pseudokirchneriella subcapitata - > 4,66 mg/l - 72 h

(OECD Test Guideline 201)

Persistence and degradability

Biodegradability aerobic - Exposure time 28 d

Result: 0 % - Not readily biodegradable. (OECD Test Guideline 301B)

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

Toxic to aquatic life. No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or

mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: - IMDG: - IATA: -

UN proper shipping name

ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

Transport hazard class(es)

ADR/RID: - IMDG: - IATA: -

Packaging group

ADR/RID: - IMDG: - IATA: -

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

Further information

Not classified as dangerous in the meaning of transport regulations.

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals
China Catalog of Hazardous chemicals 2015:Not Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
EC Inventory:Listed.
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Not Listed. website: https://www.mee.gov.cn/
Korea Existing Chemicals List (KECL):Not Listed. website: http://ncis.nier.go.kr
New Zealand Inventory of Chemicals (NZIoC):Not Listed. website: https://www.epa.govt.nz/
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Not Listed. website: https://emb.gov.ph/
Vietnam National Chemical Inventory:Not Listed. website: https://chemicaldata.gov.vn/

SECTION 16: Other information

Abbreviations and acronyms

  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • CAS: Chemical Abstracts Service
  • EC50: Effective Concentration 50%
  • IATA: International Air Transportation Association
  • IMDG: International Maritime Dangerous Goods
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • STEL: Short term exposure limit
  • TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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