Name: Semaglutide Side Chain; Semaglutide Active Ester Modifier; Semaglutide Side Chain NHS Activated Ester

Product Abbreviation: tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu

CAS No.: 1118767-15-9

Product Code: 06040003000

Storage: -20±5°C

The Semaglutide Side Chain (tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu) is a crucial protecting group for side chains in peptide synthesis. It exhibits excellent solubility and stability, effectively safeguarding amino acid side chains from nonspecific modifications or degradation during chemical reactions. Widely used in solid-phase peptide synthesis and subsequent functional group modifications, the Semaglutide Side Chain helps control reaction conditions and selectivity, minimizing side reactions to enhance product purity and yield.

I. Applications

1. Drug Modification: tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is utilized in modifying small molecule drugs, proteins, antibodies, and other bioactive molecules. By forming stable amide bonds, it enhances drug solubility, stability, or targeting specificity, thereby improving therapeutic efficacy and safety. Particularly significant in the development of long-acting peptide drugs like Semaglutide, it plays a critical role in optimizing pharmacokinetic properties and therapeutic effects.

2. Targeted Drug Delivery: Leveraging its high reactivity and biocompatibility, tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is employed in constructing targeted drug delivery systems. This facilitates precise drug release within specific tissues or cells, enhancing therapeutic efficacy while reducing side effects.

3. Biological Probes and Diagnostic Reagents: As a component of biological probes or diagnostic reagents, this compound can detect specific molecules or cellular activities within organisms, providing robust support for disease diagnosis and treatment.

II. Production and Storage

Production: The production of tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is typically carried out by specialized pharmaceutical intermediate manufacturers equipped with advanced synthesis technologies and stringent quality control systems.

Storage: It is recommended to store tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu at -20°C to ensure stability and activity.

III. Supplier Information

Currently, multiple suppliers, including but not limited to Xiamen Sinobestech Biotechnology Co., Ltd., offer tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu. These suppliers possess extensive production experience and rigorous quality control processes, ensuring high-quality products and excellent service for customers.

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