Acridine esters are a class of chemiluminescent reagents, which have a variety of models. Acridinium esters and related compounds have been widely proven to be high-quality chemiluminescent labels. The stability and detection sensitivity of acridinium esters surpass radioisotopes and label specificity. . According to the different substituents, acridine substituents commonly used as chemiluminescent labels are divided into two categories: acridine esters and acridine sulfonamides. They all share a common acridine ring in their structure. Their luminescence mechanism is the same: in an alkaline H2O2 solution, when the molecule is attacked by hydrogen peroxide ions, unstable dioxyethane is generated, which decomposes into CO2 and electronically excited N-methyl acridine Ketones emit photons with a maximum emission wavelength of 430nm when they return to the ground state.

Chemiluminescence systems such as acridine esters, 1,2-dioxetanes and peroxyoxalates, the combination of chemiluminescence and other technologies such as high performance liquid chromatography, sensor technology and flow injection technology, because It has the advantages of fast analysis speed, simple equipment, high sensitivity and wide linear range. It has been widely used in chemical food safety, biomedicine, environmental testing and other fields.

In terms of application in various fields, the acridinium ester luminescence immunoassay technology is of great help. According to the experimental principle of the double antibody sandwich method, the acridinium ester chemiluminescence immunoassay technique combined with the biotin-avidin magnetic particle separation technology is established. A detection method for quantitative determination of carcinoembryonic antigen content in serum. Due to the application of acridine ester luminescence immunotechnology, the medical determination of carcinoembryonic antigen content in serum is more rapid and simple, so that carcinoembryonic antigen patients can receive timely treatment, which provides great convenience and makes a major step forward in medicine. step. The accuracy rate of patients receiving the chemiluminescence immunoassay of acridine ester is high, fast and convenient. The accuracy of patients receiving general immunological testing is significantly lower than that of the experimental group, and the time is long and the operation is inconvenient.

In summary, the chemiluminescence immunoassay technology of acridinium ester series can be widely promoted and continued to be studied. Hubei Xindesheng Material Technology Co., Ltd. has been producing acridinium esters for more than ten years, with product purity ≥98% and high chemiluminescence efficiency. In addition, Hubei Xindesheng Materials can also provide blood collection tube additives, biological buffers, enzyme preparations, carbomer, luminol and other products. If you want to know about products, you can call for consultation. Desheng welcomes your calls.