Desheng -5 Questions and 5 Answers to the Anticoagulant Heparin Product for Blood Collection

 

Hubei Xindesheng Material Technology Co., Ltd. is a manufacturer of a complete set of blood collection additives, which are important reagents for blood pre-treatment. This step lays the foundation for the accuracy of clinical blood testing samples. Since its establishment in 2005, Desheng has independently developed more than ten types of blood collection additive products in the past 20 years, and some products have also applied for research and development patents.

 

Heparin (lithium/sodium) is one of the most commonly used anticoagulants in blood collection. Although anticoagulants all have the effect of blood anticoagulation, the use scenarios of coagulation mechanisms vary. Below, we will introduce heparin through 5 questions, and I believe you will definitely gain something after reading it.

 

1. What color is the heparin tube cap?

The caps used for different additives vary. The caps for collecting blood vessels containing heparin are green, while the caps for heparin lithium/sodium are uniformly green.

 

2. When collecting blood for testing, how much heparin should be added to achieve anticoagulant effect?

Taking 1ml of blood as an example, when detecting trace elements, adding 0.1-0.2mg of heparin per milliliter of blood can achieve anticoagulant effects.

 

3. What tests are not suitable for the anticoagulant effect of heparin?

Heparin anticoagulants can cause white blood cells to aggregate, making them unsuitable for white blood cell counting.

 

4. Introduction and main mechanism of action of heparin anticoagulants?

Heparin is an acidic mucopolysaccharide, which is stored in mast cell in the body. Such cells are distributed in the blood vessel wall, so almost all tissues and organs in the body contain some trace heparin. Under normal circumstances, the content of heparin in the blood of the human body is very low, around 9mg/L.

 

The anticoagulant effect of heparin is achieved through the following actions: ① antithrombin effect; ② The effects of anticoagulant factors Xa, IXa, XIa, XIa, and KK; ③ Inhibition of platelets; ④ Promote fibrinolysis; ⑤ Change blood viscosity. It can be summarized as enhancing the affinity between antithrombin and thrombin.  

 

5. How is heparin stored after being prepared as a solution?

In order to facilitate transportation and storage on the market, heparin is usually sold in powder form. If it is not used completely after being prepared into a solution, it should be sealed and stored below -4 ℃, and used as soon as possible. It cannot be stored for a long time.