Difference between EDTA and heparin anticoagulation

 

The word "anticoagulation" can be said to be a clich é for medical staff. These professionals always talk about it. Today, Miss Dong also brought the white people to learn about EDTA and heparin anticoagulant.

 

EDTA (ethylenediamine tetraacetate) and heparin are anticoagulants in the additives for blood collection. Their role is to prevent blood coagulation. First of all, let's understand what blood coagulation is. When coagulation factors in the blood are activated, active thrombin is formed with the participation of calcium ions; Thrombin turns soluble fibrinogen in blood into insoluble fibrinogen polymer. This kind of polymer is intricate and crisscross, and it will trap blood cells in it to form gelatinous blood clots.

 

Although both have anticoagulant effects, their principles are different. EDTA anticoagulant and calcium ions in the blood hit it off, forming a complex that inhibits the formation of active thrombin, thus achieving the anticoagulant effect. Heparin is generally extracted from the liver of larger animals, so it is named heparin. It is mostly obtained from pig intestinal mucosa and pig and cow lungs, and is a natural anticoagulant. Heparin can achieve anticoagulation mainly by indirectly inhibiting the activity of thrombin. After combining with antithrombin lll, heparin sodium or heparin lithium increases the activity of antithrombin lll and weakens the function of thrombin, so the process of fibrinogen to fibrin becomes slower, and the clotting time will be greatly prolonged.

 

Secondly, EDTA anticoagulant protects blood cell components, does not affect white blood cell count and size, has minimal effect on red blood cell morphology, and inhibits platelet aggregation. Therefore, EDTA tube is our common purple tube, which is mostly used for blood routine test. Heparin tube is a common green tube. It can be injected clinically to prevent thrombosis or embolic diseases; It is also used for hemodialysis.

 

Desheng has been developing from 2005 to today. Our R&D team has been adhering to the belief of quality first to provide high-quality products for our customers. With the concerted efforts of all members of the company, we have an important place in the blood collection market. If you want to buy relevant products, choose Desheng, you will not